Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Prevalence and comorbidity of allergic diseases in preschool children

  • Kim, Hyeong Yun (Department of Pediatrics, Bundang Jesaeng General Hospital) ;
  • Kwon, Eun Byul (Department of Pediatrics, Bundang Jesaeng General Hospital) ;
  • Baek, Ji Hyeon (Department of Pediatrics, CHA University College of Medicine) ;
  • Shin, Youn Ho (Department of Pediatrics, CHA University College of Medicine) ;
  • Yum, Hye Yung (Department of Pediatrics, Seoul Medical Center) ;
  • Jee, Hye Mi (Department of Pediatrics, CHA University College of Medicine) ;
  • Yoon, Jung Won (Department of Pediatrics, CHA University College of Medicine) ;
  • Han, Man Yong (Department of Pediatrics, CHA University College of Medicine)
  • Received : 2012.03.05
  • Accepted : 2013.05.08
  • Published : 2013.08.15
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Abstract

Purpose: Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children. Methods: We conducted a cross-sectional study comprising 615 Korean children (age, 3 to 6 years). Symptoms of allergic diseases were assessed using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire that was modified for preschool children. Comorbidities of allergic diseases were assessed by 'In the last 12 months, has your child had symptoms?'. Results: The prevalence of symptoms of asthma, allergic rhinitis, and atopic dermatitis as recorded using the ISAAC questionnaire, within the last 12 months was 13.8%, 40.7%, and 20.8%, respectively. The symptom rates of allergic conjunctivitis, food allergy, and drug allergy were 14.8%, 10.4%, and 0.8%, respectively. The prevalence of allergic rhinitis in children with asthma was 64.3% and that of asthma in children with allergic rhinitis was 21.6%. The prevalence of rhinitis in children with conjunctivitis was 64.8% and that of conjunctivitis in children with rhinitis was 23.6%. Conclusion: The prevalence of current rhinitis in our preschool children is shown to be higher than that previously reported. Allergic conjunctivitis is closely associated with asthma and allergic rhinitis. However, further studies are warranted to determine the prevalence and effects of these comorbidities on health outcomes in preschool children.

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References

  1. Aberg N, Hesselmar B, Aberg B, Eriksson B. Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 1995;25:815-9. https://doi.org/10.1111/j.1365-2222.1995.tb00023.x
  2. Lundback B. Epidemiology of rhinitis and asthma. Clin Exp Allergy 1998;28 Suppl 2:3-10.
  3. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733-43. https://doi.org/10.1016/S0140-6736(06)69283-0
  4. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998;351:1225-32. https://doi.org/10.1016/S0140-6736(97)07302-9
  5. Ahn K, Kim J, Kwon HJ, Chae Y, Hahm MI, Lee KJ, et al. The prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in Korean children: nationwide cross-sectional survey using complex sampling design. J Korean Med Assoc 2011;54:769-78. https://doi.org/10.5124/jkma.2011.54.7.769
  6. Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol 2003;112(6 Suppl):S118-27. https://doi.org/10.1016/j.jaci.2003.09.033
  7. Lack G. Pediatric allergic rhinitis and comorbid disorders. J Allergy Clin Immunol 2001;108(1 Suppl):S9-15. https://doi.org/10.1067/mai.2001.115562
  8. Rondon C, Romero JJ, Lopez S, Antunez C, Martin-Casanez E, Torres MJ, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol 2007;119:899-905. https://doi.org/10.1016/j.jaci.2007.01.006
  9. Gaugris S, Sazonov-Kocevar V, Thomas M. Burden of concomitant allergic rhinitis in adults with asthma. J Asthma 2006;43:1-7. https://doi.org/10.1080/02770900500446823
  10. Casale TB, Amin BV. Allergic rhinitis/asthma interrelationships. Clin Rev Allergy Immunol 200;21:27-49.
  11. Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK, et al. Burden of allergic rhinitis: results from the Pediatric Allergies in America survey. J Allergy Clin Immunol 2009;124(3 Suppl):S43-70. https://doi.org/10.1016/j.jaci.2009.05.013
  12. Yuksel H, Dinc G, Sakar A, Yilmaz O, Yorgancioglu A, Celik P, et al. Prevalence and comorbidity of allergic eczema, rhinitis, and asthma in a city in western Turkey. J Investig Allergol Clin Immunol 2008;18:31-5.
  13. Kim YH, Urm SH, Kim WK. Prevalence of allergic diseases and risk factors in preschool children, 2009. Pediatr Allergy Respir Dis 2011;21:165-75. https://doi.org/10.7581/pard.2011.21.3.165
  14. Kocabas CN, Civelek E, Sackesen C, Orhan F, Tuncer A, Adalioglu G, et al. Burden of rhinitis in children with asthma. Pediatr Pulmonol 2005;40:235-40. https://doi.org/10.1002/ppul.20247
  15. Bertelsen RJ, Carlsen KC, Carlsen KH. Rhinitis in children: comorbidities and phenotypes. Pediatr Allergy Immunol 2010;21(4 Pt 1):612-22. https://doi.org/10.1111/j.1399-3038.2010.01066.x
  16. Choi SW, Ju YS, Kim DS, Kim JY, Kwon HJ, Kang DH, et al. Reliability and validity of the Korean version of ISAAC questionnaire. Korean J Prev Med 1998;31:361-71.
  17. Hong SJ, Ahn KM, Lee SY, Kim KE. The prevalences of asthma and allergic diseases in Korean children. Pediatr Allergy Respir Dis 2008;18:15-25.
  18. Lee HS, Lee J, Hong SC, Kim JW, Kim SY, Lee KH. Prevalence and risk factors for allergic diseases of preschool children living in Seogwipo, Jeju, Korea. Korean J Asthma Allergy Clin Immunol 2012;32:107-14.
  19. Bousquet J, Van Cauwenberge P, Khaltaev N; Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108(5 Suppl):S147-334.
  20. Jee HM, Kim KW, Kim CS, Sohn MH, Shin DC, Kim KE. Prevalence of asthma, rhinitis and eczema in Korean children using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires. Pediatr Allergy Respir Dis 2009;19:165-72.
  21. Rosario N, Bielory L. Epidemiology of allergic conjunctivitis. Curr Opin Allergy Clin Immunol 2011;11:471-6. https://doi.org/10.1097/ACI.0b013e32834a9676
  22. Strachan D, Sibbald B, Weiland S, Ait-Khaled N, Anabwani G, Anderson HR, et al. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr Allergy Immunol 1997;8:161-76. https://doi.org/10.1111/j.1399-3038.1997.tb00156.x
  23. Peroni DG, Piacentini GL, Bodini A, Rigotti E, Pigozzi R, Boner AL. Prevalence and risk factors for atopic dermatitis in preschool children. Br J Dermatol 2008;158:539-43.
  24. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol 2003;111:661-75. https://doi.org/10.1067/mai.2003.162
  25. Zhao J, Bai J, Shen K, Xiang L, Huang S, Chen A, et al. Selfreported prevalence of childhood allergic diseases in three cities of China: a multicenter study. BMC Public Health 2010;10:551. https://doi.org/10.1186/1471-2458-10-551
  26. Li F, Zhou Y, Li S, Jiang F, Jin X, Yan C, et al. Prevalence and risk factors of childhood allergic diseases in eight metropolitan cities in China: a multicenter study. BMC Public Health 2011;11:437. https://doi.org/10.1186/1471-2458-11-437
  27. Oh JW, Kim KE, Pyun BY, Lee HR, Choung JT, Hong SJ, et al. Nationwide study for epidemiological change of atopic dermatitis in school aged children between 1995 and 2000 and kindergarten aged children in 2003 in Korea. Pediatr Allergy Respir Dis 2003; 13:227-37.
  28. Bielory L, Friedlaender MH. Allergic conjunctivitis. Immunol Allergy Clin North Am 2008;28:43-58. https://doi.org/10.1016/j.iac.2007.12.005
  29. Hesselmar B, Aberg B, Eriksson B, Aberg N. Allergic rhinoconjunctivitis, eczema, and sensitization in two areas with differing climates. Pediatr Allergy Immunol 2001;12:208-15. https://doi.org/10.1034/j.1399-3038.2001.012004208.x
  30. Lee SI, Shin MH, Lee HB, Lee JS, Son BK, Koh YY, et al. Prevalences of symptoms of asthma and other allergic diseases in Korean children: a nationwide questionnaire survey. J Korean Med Sci 2001;16:155-64.

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