Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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A 90 Day Repeated Dose-Oral Toxicity Study of Extracts from Astragalus membranaceus-Aboveground Parts in Rats

랫드를 이용한 황기의 지상부 추출물에 대한 90일 반복경구투여 독성시험

  • Park, Yeong Chul (GLP Center, Catholic University of Daegu) ;
  • Lee, Ji Sun (GLP Center, Catholic University of Daegu) ;
  • Kim, Dong Yoon (GLP Center, Catholic University of Daegu) ;
  • Son, Hye Young (GLP Center, Catholic University of Daegu) ;
  • Lee, Jung Woo (GLP Center, Catholic University of Daegu) ;
  • Cheoi, Yu Soon (Jeongseon Agricultural Extension Center) ;
  • Kim, Kwang Ki (Jeongseon Agricultural Extension Center) ;
  • Yu, Chang Yeon (Department of Applied Plant Sciences, Kangwon National University) ;
  • Chung, Ill Min (Department of Applied BioScience, Konkuk University) ;
  • Im, Moo Hyeog (Food Policy Cordination Division, Ministry of Korea Food & Drug Safety) ;
  • Lee, Kyung Jae (Forest Practice Research Center, Korea Forest Reserach Institute) ;
  • Choi, Ri Na (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Shim, Hoon Seob (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Lim, Jung Dae (Department of Herbal Medicine Resource, Kangwon National University)
  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 이지선 (대구가톨릭대학교 GLP 센터) ;
  • 김동윤 (대구가톨릭대학교 GLP 센터) ;
  • 손혜영 (대구가톨릭대학교 GLP 센터) ;
  • 이정우 (대구가톨릭대학교 GLP 센터) ;
  • 최유순 (정선군농업기술센터) ;
  • 김광기 (정선군농업기술센터) ;
  • 유창연 (강원대학교 식물자원응용공학과) ;
  • 정일민 (건국대학교 응용생물과학과) ;
  • 임무혁 (식품의약품안전처 식품정책조정과) ;
  • 이경재 (국립산림과학원 산림생산기술연구소) ;
  • 최리나 (강원대학교 생약자원개발학과) ;
  • 심훈섭 (강원대학교 생약자원개발학과) ;
  • 임정대 (강원대학교 생약자원개발학과)
  • Received : 2013.09.06
  • Accepted : 2013.11.27
  • Published : 2013.12.30
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Abstract

Pharmacological studies and clinical practices have indicated that Radix Astragali, a dried root of Astragalus membranaceus possesses a lot of biological activities, including antioxidant, hepatoprotective, anti-diabetic, tonic, diuretic, antimicrobial, antiviral, and immunological activities. These biological activities approved by the modern pharmacological studies are mainly due to the constituents of Astragalus membranaceus including polysaccharides, saponins, flavonoids, amino acids, and trace elements. In resent, the main constituents in the root part showing a lot of biological activities has been isolated also from the aboveground parts such as leaves and sprouts in our laboratory. However, the safety evaluation for the aboveground parts of Astragalus membranaceus should be checked before expanding their application as one of food. In the study, a 90-day rat oral gavage study has been conducted with the extracts from Astragalus membranaceus-above-ground parts at doses of 1000, 3000, and 5000mg/kg/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000mg/kg/day of the water-extracts from Astragalus membranaceus-aboveground parts.

Keywords

References

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