전자공학회논문지 (Journal of the Institute of Electronics and Information Engineers)

  • 제50권12호
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  • Pages.261-269
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  • 2013
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  • 2287-5026(pISSN)
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  • 2288-159X(eISSN)
대한전자공학회 (The Institute of Electronics and Information Engineers)
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지연보상 위너 필터링에 의한 유발전위 파형개선

Enhancement of Evoked Potential Waveform using Delay-compensated Wiener Filtering

  • 이지은 (연세대학교 일반대학원 생체공학협동과정) ;
  • 유선국 (연세대학교 의과대학 의학공학교실)
  • Lee, JeeEun (Graduate School of Biomedical Engineering, Yonsei University) ;
  • Yoo, Sun K. (Department of Medical Engineering, Yonsei University College of Medicine)
  • 투고 : 2013.08.12
  • 심사 : 2013.11.27
  • 발행 : 2013.12.25
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초록

본 연구에서는 자극에 대한 유발전위 발현시점의 변화와 유발전위에 혼입된 무작위 잡음을 시간지연현상과 자음혼입 가법모형으로 모델링 하였다. 동기시점 불일치에 따른 평균화 처리과정의 유발전위 신호의 왜곡을 개선하기 위하여 시간지연추정을 잡음제거 위너필터에 결합한 복합적 시간지연보상-잡음개선 위너필터-앙상블평균 처리기법 (DWEA: Delay compensated Wiener filtered ensemble averaging)을 적용하였다. 제시한 방법의 성능은 임의의 시간지연과 크기의 변화를 변화시킨 백색잡음 데이터를 합성한 대리모의실험을 통하여 검증하였다. 모의실험데이터에 대하여 DWEA 방법이 위너필터링앙상블평균 방법과 기존의 앙상블평균방법보다 우수 하였다. DWEA 방법은 10% MSE 오차한계에 대하여 잡음이득 7까지 동작 가능하였다. 실험결과를 통하여 DWEA 방법은 잡음의 혼입과 동기 불일치 현상을 보이는 유발전위의 신호개선의 가능성을 제시하였다.

In this paper, the evoked potential(EP) was represented by additive delay model to comply with the variational noisy response of stimulus-event synchronization. The hybrid method of delay compensated-Wiener filtered-ensemble averaging(DWEA) was proposed to enhance the EP signal distortion occurred during averaging procedure due to synchronization timing mismatch. The performance of DWEA has been tested by surrogated simulation, which is composed of synthesized arbitrary delay and arbitrary level of added noise. The performance of DWEA is better than those of Wiener filtered-ensemble averaging and of conventional ensemble averaging. DWEA is endurable up to added noise gain of 7 for 10 % mean square error limit. Throughout the experimentation observation, it has been demonstrated that DWEA can be applied to enhance the evoked potential having the synchronization mismatch with added noise.

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