The Journal of the Korean dental association (대한치과의사협회지)

The Korean Dental Association (대한치과의사협회)
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New biomarkers of dental caries: nitric oxide and glutathione

임상가를 위한 특집 3 - 치아우식증의 새로운 생체지표: nitric oxide와 glutathione

  • Han, Dong-Hun (Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University) ;
  • Kim, Min-Ji (Department of Preventive and Community Dentistry, School of Dentistry, Pusan National University) ;
  • Jun, Eun-Joo (Department of Preventive and Community Dentistry, School of Dentistry, Pusan National University) ;
  • Kim, Jin-Bom (Department of Preventive and Community Dentistry, School of Dentistry, Pusan National University)
  • 한동헌 (서울대학교 치의학대학원 예방치학교실) ;
  • 김민지 (부산대학교 치의학전문대학원 예방치과학교실) ;
  • 전은주 (부산대학교 치의학전문대학원 예방치과학교실) ;
  • 김진범 (부산대학교 치의학전문대학원 예방치과학교실)
  • Received : 2012.08.04
  • Accepted : 2012.08.09
  • Published : 2012.09.01
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Abstract

Dental caries is multifactorial local disease which involves destruction of the hard tissues of the teeth by metabolities produces by microorganisms. Recently, there has been growing interest in the role of nitric oxide (NO) and glutathione (GSH) in caries incidence. The aim of the study was to survey the studies reported the association among salivary NO, GSH and dental careis. Three studies reported the association between NO and dental caries. However, the results were contradictory. Only one study showed negative association between GSH and dental caries. In Korea, NO showed negative association with Lactobacilli and GSH showed positive association with dental caries. These observations suggest the possibility that NO and GSH could be new biomarkers for dental caries. However, further study should be needed.

Keywords

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