Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Total Synthesis of Azasugar 1,4-Dideoxy-1,4-imino-D-galacitol

  • Received : 2012.07.17
  • Accepted : 2012.07.31
  • Published : 2012.11.20
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Abstract

A new highly stereoselective synthesis of pyrrolidine azasugar 1,4-dideoxy-1,4-imino-D-galacitol is being reported herein. The synthesis was achieved in a linear sequence and inexpensive chiral source (+)-diethyl tartarate was used as the starting material. The key step involved during the synthesis was Pd catalysed amino cyclization of alkenylamine, Bose modified Mitsunobu reaction and Sharpless asymmetric dihydroxylation.

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References

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