Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Inhibitory Effect of PG-Platycodin D on the Development of Atopic Dermatitis-Like Skin Lesions in ICR Mice

Platycodin D를 포함하는 도라지 추출물이 DNCB 유도 알레르기성 아토피 피부염에 미치는 영향

  • Park, Sae-Jin (Division of Biological Science and Technology, College of Science and Technology, Yonsei University) ;
  • Kim, Yoon Suk (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
  • Kim, Tack-Joong (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
  • 박세진 (연세대학교 과학기술대학 생명과학기술학부) ;
  • 김윤석 (연세대학교 보건과학대학 임상병리학과) ;
  • 김택중 (연세대학교 과학기술대학 생명과학기술학부)
  • Received : 2012.07.20
  • Accepted : 2012.10.22
  • Published : 2012.10.30
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Abstract

Atopic dermatitis is characterized by chronically pruritic and inflammatory dermatitis. In this study, we investigated the effect of Platycodon grandiflorum including platycodin D (PG-Platycodin D) in an atopic dermatitis-like mouse model. An atopic dermatitis-like skin lesion was induced by repeated treatment of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of ICR mice. The efficacy of PG-Platycodin D was tested by observing scratching behavior, the skin severity score, and histopathologic analysis. PG-Platycodin D reduced the DNCB-induced increase in scratching behavior and the skin severity score. In addition, histopathologic analysis revealed a reduction in the thickening of the epidermis in the PG-Platycodin D group. These results may contribute to the development of a therapeutic drug for the treatment of atopic dermatitis.

알레르기성 아토피 피부염은 면역적 반응을 포함하는 복잡한 원인을 가진 염증성 질환이다. 본 연구는 ICR mice의 등쪽 부위에 반복적인 DNCB 도포를 통해 유발시킨 알레르기성 아토피 피부염에 있어서 PG-Platycodin D의 효능에 대해 연구하였다. PG-Platycodin D의 효능은 scratching behavior, skin severity score, 그리고 조직병리학적 관찰을 통해서 확인하였다. PG-Platycodin D가 scratching behavior, skin severity score 수준을 감소시킴을 확인할 수 있었다. 또한, 조직병리학적 관찰에 의해 PG-Platycodin D군에서 피부의 부종이 효과적으로 억제됨을 알 수 있었다. 이러한 결과로부터 알레르기성 아토피 피부염에 있어서 Platycodin D가 포함된 도라지 추출물이 유용한 천연 원료 물질로서 가능성을 가짐을 확인하였다.

Keywords

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