YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibitory Effects on Platelet Aggregation and Blood Coagulation by Concurrent Administration of Trifusal and Ibudilast

Triflusal과 Ibudilast 동시처리에 의한 혈소판응집 및 혈액응고 억제효과

  • Hwang, In-Young (College of Pharmacy, Duksung Women's University) ;
  • Sohn, Yoon-Ah (College of Pharmacy, Duksung Women's University) ;
  • Hwang, Seon-A (College of Pharmacy, Duksung Women's University) ;
  • Koo, Yean-Kyoung (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kim, Sun-Young (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • YunChoi, Hye-Sook (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kwon, Soon-Kyoung (College of Pharmacy, Duksung Women's University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
  • 황인영 (덕성여자대학교 약학대학) ;
  • 손윤아 (덕성여자대학교 약학대학) ;
  • 황선아 (덕성여자대학교 약학대학) ;
  • 구연경 (서울대학교 천연물과학연구소) ;
  • 김선영 (서울대학교 천연물과학연구소) ;
  • 윤혜숙 (서울대학교 천연물과학연구소) ;
  • 권순경 (덕성여자대학교 약학대학) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Received : 2012.05.30
  • Accepted : 2012.06.30
  • Published : 2012.08.31
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Abstract

This study aims to develop a novel regimen for enhanced efficacy and reduced side effect in inhibiting platelet aggregation and blood coagulation by concurrent administration of triflusal and ibudilast as anticoaggulants. The result shows this combination of triflusal and ibudilast (300~500 ${\mu}M$, respectively) has additive effect in inhibiting platelet aggregation and blood coagulation over the administration of truflusal or ibdilast as a single treatment. This pharmaceutical composition is expected to be useful for the prevention or treatment of various diseases and symptoms, for example, ischemic heart disease, ischemic cerebral infarction, arteriosclerosis, and thrombosis caused by the insertion of a stent.

Keywords

References

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