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Long-Term Follow-Up Radiologic and Clinical Evaluation of Cylindrical Cage for Anterior Interbody Fusion in Degenerative Cervical Disc Disease

  • Kim, Su-Hyeong (Department of Neurosurgery, Hanyang University Medical Center) ;
  • Chun, Hyoung-Joon (Department of Neurosurgery, Hanyang University Medical Center) ;
  • Yi, Hyeon-Joong (Department of Neurosurgery, Hanyang University Medical Center) ;
  • Bak, Koang-Hum (Department of Neurosurgery, Hanyang University Medical Center) ;
  • Kim, Dong-Won (Department of Anesthesiology, Hanyang University Medical Center) ;
  • Lee, Yoon-Kyoung (Red Cross College of Nursing, Chung-Ang University)
  • 투고 : 2012.02.23
  • 심사 : 2012.08.19
  • 발행 : 2012.08.28

초록

Objective : Various procedures have been introduced for anterior interbody fusion in degenerative cervical disc disease including plate systems with autologous iliac bone, carbon cages, and cylindrical cages. However, except for plate systems, the long-term results of other methods have not been established. In the present study, we evaluated radiologic findings for cylindrical cervical cages over long-term follow up periods. Methods : During 4 year period, radiologic findings of 138 patients who underwent anterior cervical fusion with cylindrical cage were evaluated at 6, 12, 24, and 36 postoperative months using plain radiographs. We investigated subsidence, osteophyte formation (anterior and posterior margin), cage direction change, kyphotic angle, and bone fusion on each radiograph. Results : Among the 138 patients, a minimum of 36 month follow-up was achieved in 99 patients (mean follow-up : 38.61 months) with 115 levels. Mean disc height was 7.32 mm for preoperative evaluations, 9.00 for immediate postoperative evaluations, and 4.87 more than 36 months after surgery. Osteophytes were observed in 107 levels (93%) of the anterior portion and 48 levels (41%) of the posterior margin. The mean kyphotic angle was $9.87^{\circ}$ in 35 levels showing cage directional change. There were several significant findings : 1) related subsidence [T-score (p=0.039) and anterior osteophyte (p=0.009)], 2) accompanying posterior osteophyte and outcome (p=0.05). Conclusion : Cage subsidence and osteophyte formation were radiologically observed in most cases. Low T-scores may have led to subsidence and kyphosis during bone fusion although severe neurologic aggravation was not found, and therefore cylindrical cages should be used in selected cases.

키워드

참고문헌

  1. al-Hami S : Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. Minim Invasive Neurosurg 42 : 10-17, 1999 https://doi.org/10.1055/s-2008-1053361
  2. Arrington ED, Smith WJ, Chambers HG, Bucknell AL, Davino NA : Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res : 300-309, 1996
  3. Auguste KI, Chin C, Acosta FL, Ames CP : Expandable cylindrical cages in the cervical spine : a review of 22 cases. J Neurosurg Spine 4 : 285-291, 2006 https://doi.org/10.3171/spi.2006.4.4.285
  4. Bartels RH, Donk RD, Feuth T : Subsidence of stand-alone cervical carbon fiber cages. Neurosurgery 58 : 502-508; discussion 502-508, 2006 https://doi.org/10.1227/01.NEU.0000197258.30821.50
  5. Benneker LM, Heini PF, Anderson SE, Alini M, Ito K : Correlation of radiographic and MRI parameters to morphological and biochemical assessment of intervertebral disc degeneration. Eur Spine J 14 : 27-35, 2005 https://doi.org/10.1007/s00586-004-0759-4
  6. Bishop RC, Moore KA, Hadley MN : Anterior cervical interbody fusion using autogeneic and allogeneic bone graft substrate : a prospective comparative analysis. J Neurosurg 85 : 206-210, 1996 https://doi.org/10.3171/jns.1996.85.2.0206
  7. Bohlman HH, Eismont FJ : Surgical techniques of anterior decompression and fusion for spinal cord injuries. Clin Orhtop : 57-67, 1981
  8. Bovim G, Schrader H, Sand T : Neck pain in the general population. Spine (Phila Pa 1976) 19 : 1307-1309, 1994 https://doi.org/10.1097/00007632-199406000-00001
  9. Brodke DS, Zdeblick TA : Modified Smith-Robinson procedure for anterior cervical discectomy and fusion. Spine (Phila Pa 1976) 17 : S427-S430, 1992 https://doi.org/10.1097/00007632-199210001-00014
  10. Brown TD, Pedersen DR, Gray ML, Brand RA, Rubin CT : Toward an identification of mechanical parameters initiating periosteal remodeling : a combined experimental and analytic approach. J Biomech 23 : 893-905, 1990 https://doi.org/10.1016/0021-9290(90)90354-6
  11. Buckwalter JA : Aging and degeneration of the human intervertebral disc. Spine (Phila Pa 1976) 20 : 1307-1314, 1995 https://doi.org/10.1097/00007632-199506000-00022
  12. Emery SE, Bolesta MJ, Banks MA, Jones PK : Robinson anterior cervical fusion comparison of the standard and modified techniques. Spine (Phila Pa 1976) 19 : 660-663, 1994 https://doi.org/10.1097/00007632-199403001-00004
  13. Fernyhough JC, White JI, LaRocca H : Fusion rates in multilevel cervical spondylosis comparing allograft fibula with autograft fibula in 126 patients. Spine (Phila Pa 1976) 16 : S561-S564, 1991 https://doi.org/10.1097/00007632-199110001-00022
  14. Fountas KN, Kapsalaki EZ, Smith BE, Nikolakakos LG, Richardson CH, Smisson HF, et al. : Interobservational variation in determining fusion rates in anterior cervical discectomy and fusion procedures. Eur Spine J 16 : 39-45, 2007 https://doi.org/10.1007/s00586-006-0116-x
  15. Goel VK, Ramirez SA, Kong W, Gilbertson LG : Cancellous bone Young's modulus variation within the vertebral body of a ligamentous lumbar spine--application of bone adaptive remodeling concepts. J Biomech Eng 117 : 266-271, 1995 https://doi.org/10.1115/1.2794180
  16. Gore DR, Sepic SB, Gardner GM : Roentgenographic findings of the cervical spine in asymptomatic people. Spine (Phila Pa 1976) 11 : 521-524, 1986 https://doi.org/10.1097/00007632-198607000-00003
  17. Graham JJ : Complications of cervical spine surgery. A five-year report on a survey of the membership of the Cervical Spine Research Society by the Morbidity and Mortality Committee. Spine (Phila Pa 1976) 14 : 1046-1050, 1989 https://doi.org/10.1097/00007632-198910000-00003
  18. Grob D, Frauenfelder H, Mannion AF : The association between cervical spine curvature and neck pain. Eur Spine J 16 : 669-678, 2007 https://doi.org/10.1007/s00586-006-0254-1
  19. Hald HJ, Danz B, Schwab R, Burmeister K, Bähren W : [Radiographically demonstrable spinal changes in asymptomatic young men]. Rofo 163 : 4-8, 1995 https://doi.org/10.1055/s-2007-1015936
  20. Hida K, Iwasaki Y, Yano S, Akino M, Seki T : Long-term follow-up results in patients with cervical disk disease treated by cervical anterior fusion using titanium cage implants. Neurol Med Chir (Tokyo) 48 : 440-446; discussion 446, 2008 https://doi.org/10.2176/nmc.48.440
  21. Hwang SL, Hwang YF, Lieu AS, Lin CL, Kuo TH, Su YF, et al. : Outcome analyses of interbody titanium cage fusion used in the anterior discectomy for cervical degenerative disc disease. J Spinal Disord Tech 18 : 326-331, 2005 https://doi.org/10.1097/01.bsd.0000164198.30725.2d
  22. Juhl JH, Miller SM, Roberts GW : Roentgenographic variations in the normal cervical spine. Radiology 78 : 591-597, 1962 https://doi.org/10.1148/78.4.591
  23. Joung YI, Oh SH, Ko Y, Yi HJ, Lee SK : Subsidence of cylindrical cage (AMSLUtrade mark Cage) : postoperative 1 year follow-up of the cervical anterior interbody fusion. J Korean Neurosurg Soc 42 : 367-370, 2007 https://doi.org/10.3340/jkns.2007.42.5.367
  24. Katsuura A, Hukuda S, Saruhashi Y, Mori K : Kyphotic malalignment after anterior cervical fusion is one of the factors promoting the degenerative process in adjacent intervertebral levels. Eur Spine J 10 : 320-324, 2001 https://doi.org/10.1007/s005860000243
  25. Kim YE, Goel VK, Weinstein JN, Lim TH : Effect of disc degeneration at one level on the adjacent level in axial mode. Spine (Phila Pa 1976) 16 : 331-335, 1991 https://doi.org/10.1097/00007632-199103000-00013
  26. Kolstad F, Nygaard $\phi$P, Andresen H, Leivseth G : Anterior cervical arthrodesis using a "stand alone" cylindrical titanium cage : prospective analysis of radiographic parameters. Spine (Phila Pa 1976) 35 : 1545-1550, 2010 https://doi.org/10.1097/BRS.0b013e3181d259c1
  27. Kumaresan S, Yoganandan N, Pintar FA : Finite element analysis of anterior cervical spine interbody fusion. Biomed Mater Eng 7 : 221-230, 1997
  28. Kumaresan S, Yoganandan N, Pintar FA, Maiman DJ, Goel VK : Contribution of disc degeneration to osteophyte formation in the cervical spine : a biomechanical investigation. J Orthop Res 19 : 977-984, 2001 https://doi.org/10.1016/S0736-0266(01)00010-9
  29. Lopez-Espina CG, Amirouche F, Havalad V : Multilevel cervical fusion and its effect on disc degeneration and osteophyte formation. Spine (Phila Pa 1976) 31 : 972-978, 2006 https://doi.org/10.1097/01.brs.0000215205.66437.c3
  30. López-Oliva Muñoz F, García de las Heras B, Concejero López V, Asenjo Siguero JJ : Comparison of three techniques of anterior fusion in single-level cervical disc herniation. Eur Spine J 7 : 512-516, 1998 https://doi.org/10.1007/s005860050117
  31. Majd ME, Vadhva M, Holt RT : Anterior cervical reconstruction using titanium cages with anterior plating. Spine (Phila Pa 1976) 24 : 1604-1610, 1999 https://doi.org/10.1097/00007632-199908010-00016
  32. Matge G : Anterior interbody fusion with the BAK-cage in cervical spondylosis. Acta Neurochir (Wien) 140 : 1-8, 1998 https://doi.org/10.1007/s007010050049
  33. Nathan H : Osteophytes of the vertebral column. Ananatomical study of their development according to age, race and sex with considerations as to their etiology and significance. J Bone Joint Surg 44 : 243-268, 1962 https://doi.org/10.2106/00004623-196244020-00003
  34. Nojiri K, Matsumoto M, Chiba K, Maruiwa H, Nakamura M, Nishizawa T, et al. : Relationship between alignment of upper and lower cervical spine in asymptomatic individuals. J Neurosurg 99 : 80-83, 2003
  35. Odom GL, Finney W, Woodhall B : Cervical disk lesions. J Am Med Assoc 166 : 23-28, 1958 https://doi.org/10.1001/jama.1958.02990010025006
  36. Orr RD, Zdeblick TA : Cervical spondylotic myelopathy. Approaches to surgical treatment. Clin Orthop Relat Res : 58-66, 1999
  37. Robertson JT, Papadopoulos SM, Traynelis VC : Assessment of adjacent-segment disease in patients treated with cervical fusion or arthroplasty : a prospective 2-year study. J Neurosurg Spine 3 : 417-423, 2005 https://doi.org/10.3171/spi.2005.3.6.0417
  38. Robinson RA, Smith GW : Anterior cervical disc removal and interbody fusion for cervical disc syndrome. Bull Johns Hopkins Hosp 96 : 223-224, 1955
  39. Sawin PD, Traynelis VC, Menezes AH : A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg 88 : 255-265, 1998 https://doi.org/10.3171/jns.1998.88.2.0255
  40. Senter HJ, Kortyna R, Kemp WR : Anterior cervical discectomy with hydroxylapatite fusion. Neurosurgery 25 : 39-42; discussion 42-43, 1989 https://doi.org/10.1227/00006123-198907000-00007
  41. Thomé C, Krauss JK, Zevgaridis D : A prospective clinical comparison of rectangular titanium cages and iliac crest autografts in anterior cervical discectomy and fusion. Neurosurg Rev 27 : 34-41, 2004 https://doi.org/10.1007/s10143-003-0297-2
  42. Türeyen K : Disc height loss after anterior cervical microdiscectomy with titanium intervertebral cage fusion. Acta Neurochir (Wien) 145 : 565-569; discussion 569-570, 2003 https://doi.org/10.1007/s00701-003-0050-1
  43. Wilke HJ, Kettler A, Goetz C, Claes L : Subsidence resulting from simulated postoperative neck movements : an in vitro investigation with a new cervical fusion cage. Spine (Phila Pa 1976) 25 : 2762-2770, 2000 https://doi.org/10.1097/00007632-200011010-00008

피인용 문헌

  1. Surgical Outcome of a Zero-profile Device Comparing with Stand-alone Cage and Anterior Cervical Plate with Iliac Bone Graft in the Anterior Cervical Discectomy and Fusion vol.11, pp.3, 2014, https://doi.org/10.14245/kjs.2014.11.3.169
  2. Evaluation of bony fusion after anterior cervical discectomy: a systematic literature review vol.28, pp.2, 2012, https://doi.org/10.1007/s00586-018-5820-9