Bulletin of the Korean Chemical Society

  • 제33권10호
  • /
  • Pages.3417-3422
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  • 2012
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Antiviral Activity of 3-Aminoindole Nucleosides of 2-Acetamido-2-deoxy-D-glucose

  • Abdel-Rahman, Adel A.H. (Department of Chemistry, Faculty of Science, Menoufia University) ;
  • El-Latif, Mona M. Abd (Dean of Advanced Technology and New Materials Research Institute, City for Scientific Research and Technology Applications) ;
  • El-Essawy, Farag A. (Department of Chemistry, Faculty of Science, Menoufia University) ;
  • Barakat, Yousif A. (Department of Chemistry, Faculty of Science, Menoufia University)
  • 투고 : 2012.02.14
  • 심사 : 2012.06.21
  • 발행 : 2012.10.20
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초록

A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.

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