Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Alveolar Soft Part Sarcoma Metastasized to Both the Skull and the Brain

  • Shin, Tae-Hee (Department of Neurosurgery, Yeungnam University College of medicine) ;
  • Jung, Young-Jin (Department of Neurosurgery, Yeungnam University College of medicine) ;
  • Kim, Oh-Lyong (Department of Neurosurgery, Yeungnam University College of medicine) ;
  • Kim, Min-Su (Department of Neurosurgery, Yeungnam University College of medicine)
  • Received : 2011.11.30
  • Accepted : 2012.07.16
  • Published : 2012.07.28
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Abstract

Alveolar soft part sarcoma (ASPS) with skull and brain metastases is extremely rare. A 53-year-old patient diagnosed as skull metastasis of ASPS visited our clinic complaining of an outgrowing scalp mass in spite of radiation therapy. Past medical history revealed that the patient had been diagnosed and treated for ASPS of the thigh 4 years ago. Magnetic resonance imaging revealed a hyperintense ovoid mass on the T2-weighted image, an isointense on the T1-weighted image, and a homogeneous enhanced mass with gadolinium. Another small-sized enhanced mass with mild peritumoral swelling was found at the deep white matter of the left frontal lobe. A gross total resection of the skull lesion with cranioplasty was performed for the surgical defect. A histologic examination of the specimens revealed metastatic ASPS involving the skull. Surgery with a total removal of the lesions may be effective for improving a patient's symptoms especially from neurological dysfunction.

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References

  1. Argani P, Lal P, Hutchinson B, Lui MY, Reuter VE, Ladanyi M : Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions : a sensitive and specific immunohistochemical assay. Am J Surg Pathol 27 : 750-761, 2003 https://doi.org/10.1097/00000478-200306000-00005
  2. Bindal RK, Sawaya RE, Leavens ME, Taylor SH, Guinee VF : Sarcoma metastatic to the brain : results of surgical treatment. Neurosurgery 35 : 185-190; discussion 190-191, 1994 https://doi.org/10.1227/00006123-199408000-00002
  3. Chang EL, Selek U, Hassenbusch SJ 3rd, Maor MH, Allen PK, Mahajan A, et al. : Outcome variation among "radioresistant" brain metastases treated with stereotactic radiosurgery. Neurosurgery 56 : 936-945; discussion 936-945, 2005
  4. Christopherson WM, Foote FW Jr, Stewart FW : Alveolar soft-part sarcomas; structurally characteristic tumors of uncertain histogenesis. Cancer 5 : 100-111, 1952 https://doi.org/10.1002/1097-0142(195201)5:1<100::AID-CNCR2820050112>3.0.CO;2-K
  5. Evans HL : Alveolar soft-part sarcoma. A study of 13 typical examples and one with a histologically atypical component. Cancer 55 : 912-917, 1985 https://doi.org/10.1002/1097-0142(19850215)55:4<912::AID-CNCR2820550434>3.0.CO;2-G
  6. Fassbender HG : [Alveolar myoblastic sarcoma of the skeletal musculature]. Oncologia 13 : 184-191, 1960 https://doi.org/10.1159/000224045
  7. Fox BD, Patel A, Suki D, Rao G : Surgical management of metastatic sarcoma to the brain. J Neurosurg 110 : 181-186, 2009 https://doi.org/10.3171/2008.4.17505
  8. Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, et al. : The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene 20 : 48-57, 2001 https://doi.org/10.1038/sj.onc.1204074
  9. Lewis AJ : Sarcoma metastatic to the brain. Cancer 61 : 593-601, 1988 https://doi.org/10.1002/1097-0142(19880201)61:3<593::AID-CNCR2820610329>3.0.CO;2-Z
  10. Lieberman PH, Foote FW Jr, Stewart FW, Berg JW : Alveolar soft-partsarcoma. JAMA 198 : 1047-1051, 1966 https://doi.org/10.1001/jama.1966.03110230063012
  11. Lokich JJ : The management of cerebral metastasis. JAMA 234 : 748-751, 1975 https://doi.org/10.1001/jama.1975.03260200064027
  12. Miettinen M, Ekfors T : Alveolar soft part sarcoma. Immunohistochemical evidence for muscle cell differentiation. Am J Clin Pathol 93 : 32-38, 1990 https://doi.org/10.1093/ajcp/93.1.32
  13. Mukai M, Torikata C, Iri H, Mikata A, Hanaoka H, Kato K, et al. : Histogenesis of alveolar soft part sarcoma. An immunohistochemical and biochemical study. Am J Surg Pathol 10 : 212-218, 1986 https://doi.org/10.1097/00000478-198603000-00008
  14. Ogose A, Morita T, Hotta T, Kobayashi H, Otsuka H, Hirata Y, et al. : Brain metastases in musculoskeletal sarcomas. Jpn J Clin Oncol 29 : 245-247, 1999 https://doi.org/10.1093/jjco/29.5.245
  15. Okada K, Takeda F, Kawafuchi J, Suzuki Y : [Skull and cerebral metastases of alveolar soft-part sarcoma. A report of an autopsy case (author's transl)]. No Shinkei Geka 2 : 481-486, 1974
  16. Perry JR, Bilbao JM : Metastatic alveolar soft part sarcoma presenting as a dural-based cerebral mass. Neurosurgery 34 : 168-170, 1994 https://doi.org/10.1227/00006123-199401000-00024
  17. Portera CA Jr, Ho V, Patel SR, Hunt KK, Feig BW, Respondek PM, et al. : Alveolar soft part sarcoma : clinical course and patterns of metastasis in 70 patients treated at a single institution. Cancer 91 : 585-591, 2001 https://doi.org/10.1002/1097-0142(20010201)91:3<585::AID-CNCR1038>3.0.CO;2-0
  18. Ronald AW, David MB, Frederick HS, Adele TM : Histopathogenesis of Alveolar soft part sarcoma. Cancer 29 : 191-204, 1972 https://doi.org/10.1002/1097-0142(197201)29:1<191::AID-CNCR2820290129>3.0.CO;2-#
  19. Salvati M, Cervoni L, Caruso R, Gagliardi FM, Delfini R : Sarcoma metastatic to the brain : a series of 15 cases. Surg Neurol 49 : 441-444, 1998 https://doi.org/10.1016/S0090-3019(97)00034-7
  20. Salvati M, D'Elia A, Frati A, Santoro A : Sarcoma metastatic to the brain : a series of 35 cases and considerations from 27 years of experience. J Neurooncol 98 : 373-377, 2010 https://doi.org/10.1007/s11060-009-0085-0
  21. Wroński M, Arbit E, Burt M, Perino G, Galicich JH, Brennan MF : Resection of brain metastases from sarcoma. Ann Surg Oncol 2 : 392-399, 1995 https://doi.org/10.1007/BF02306371
  22. Yoshida S, Morii K, Watanabe M, Saito T : Brain metastasis in patients with sarcoma : an analysis of histological subtypes, clinical characteristics, and outcomes. Surg Neurol 54 : 160-164, 2000 https://doi.org/10.1016/S0090-3019(00)00293-7

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