Journal of Korean Neurosurgical Society

  • 제52권1호
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  • Pages.32-36
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  • 2012
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Electrophysiological and Behavioral Changes by Phosphodiesterase 4 Inhibitor in a Rat Model of Alcoholic Neuropathy

  • Han, Kyoung-Hee (Department of Obstetrics and Gynecology, Yonsei University Wonju College of Medicine) ;
  • Kim, Sung-Hoon (Department of Rehabilitation Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine) ;
  • Jeong, In-Cheol (Department of Anesthesiology and Pain Medicine, Seoul National University Hospital) ;
  • Lee, Young-Hee (Department of Rehabilitation Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine) ;
  • Chang, Sei-Jin (Department of Preventive Medicine and Institute of Occupational Medicine, Institute of Occupational & Environmental Medicine, Yonsei University Wonju College of Medicine) ;
  • Park, Bit-Na-Ri (Department of Rehabilitation Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine) ;
  • Kim, Seok-Won (Department of Neurosurgery, College of Medicine, Chosun University)
  • 투고 : 2011.09.23
  • 심사 : 2012.07.19
  • 발행 : 2012.07.28
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초록

Objective : Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of the present study is to investigate the effect of rolipram, a phosphodiesterase 4 inhibitor, against alcohol-induced neuropathy in rats. Methods : Allodynia was induced by administering 35% v/v ethanol (10 g/kg; oral gavage) to Spraue-Dawley rats for 8 weeks. Rolipram and saline (vehicle) were administered intraperitoneally. Mechanical allodynia was measured by using von Frey filaments. Somatosensory evoked potential (SEP) was proposed as complementary measure to assess the integrity of nerve pathway. Results : The ethanol-induced mechanical allodynia began to manifest from 3 week, and then peaked within 1 week. Beginning from 3 week, latency significantly started to increased in control group. In rolipram treated rats, the shorter latency was sustained until 8 weeks (p<0.05). The mechanical allodynia, which began to manifest on the 3 weeks, intraperitoneal injections of rolipram sustained statistical difference until 8 weeks, the final week of the study (p<0.05). Conclusion : This study suggests that rolipram might alleviate mechanical allodynia induced by alcohol in rats, which clearly has clinical implication.

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참고문헌

  1. Atkins CM, Oliva AA Jr, Alonso OF, Pearse DD, Bramlett HM, Dietrich WD : Modulation of the cAMP signaling pathway after traumatic brain injury. Exp Neurol 208 : 145-158, 2007 https://doi.org/10.1016/j.expneurol.2007.08.011
  2. Bosch EP, Pelham RW, Rasool CG, Chatterjee A, Lash RW, Brown L, et al. : Animal models of alcoholic neuropathy : morphologic, electrophysiologic, and biochemical findings. Muscle Nerve 2 : 133-144, 1979 https://doi.org/10.1002/mus.880020208
  3. Brain WR, Walton JN : Disorders of peripheral nerves : alcoholoc polyneuritis. Brain's deseases of the nervous system, 7th ed. London : Oxford, 1969, pp817-819
  4. Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP, et al. : NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J Immunol 153 : 712-723, 1994
  5. Corsetti G, Rezzani R, Rodella L, Bianchi R : Ultrastructural study of the alterations in spinal ganglion cells of rats chronically fed on ethanol. Ultrastruct Pathol 22 : 309-319, 1998 https://doi.org/10.3109/01913129809103352
  6. Dina OA, Barletta J, Chen X, Mutero A, Martin A, Messing RO, et al. : Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. J Neurosci 20 : 8614-8619, 2000
  7. Dixon WJ : Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20 : 441-462, 1980 https://doi.org/10.1146/annurev.pa.20.040180.002301
  8. Fillmore KM : Women's drinking across the adult life course as compared to men's. Br J Addict 82 : 801-811, 1987 https://doi.org/10.1111/j.1360-0443.1987.tb01547.x
  9. Floyd RA : Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 222 : 236-245, 1999 https://doi.org/10.1046/j.1525-1373.1999.d01-140.x
  10. Floyd RA, Hensley K : Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23 : 795-807, 2002 https://doi.org/10.1016/S0197-4580(02)00019-2
  11. Gomberg ES : Women and alcohol : use and abuse. J Nerv Ment Dis 181 : 211-219, 1993 https://doi.org/10.1097/00005053-199304000-00001
  12. Hou S, Guan H, Ricciardi RP : Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding. J Biol Chem 278 : 45994-45998, 2003 https://doi.org/10.1074/jbc.M307971200
  13. Hu S, Peterson PK, Chao CC : Cytokine-mediated neuronal apoptosis. Neurochem Int 30 : 427-431, 1997 https://doi.org/10.1016/S0197-0186(96)00078-2
  14. Keeling KL, Hicks RR, Mahesh J, Billings BB, Kotwal GJ : Local neutrotriesphil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system. J Neuroimmunol 105 : 20-30, 2000 https://doi.org/10.1016/S0165-5728(00)00183-1
  15. Kinoshita K, Chatzipanteli K, Vitarbo E, Truettner JS, Alonso OF, Dietrich WD : Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats : importance of injury severity and brain temperature. Neurosurgery 51 : 195-203; discussion 2003, 2002 https://doi.org/10.1097/00006123-200207000-00027
  16. Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, et al. : Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol 54 : 19-29, 2003 https://doi.org/10.1002/ana.10550
  17. Lander HM : An essential role for free radicals and derived species in signal transduction. FASEB J 11 : 118-124, 1997 https://doi.org/10.1096/fasebj.11.2.9039953
  18. Manganiello VC, Murata T, Taira M, Belfrage P, Degerman E : Diversity in cyclic nucleotide phosphodiesterase isoenzyme families. Arch Biochem Biophys 322 : 1-13, 1995 https://doi.org/10.1006/abbi.1995.1429
  19. Mayr B, Montminy M : Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2 : 599-609, 2001 https://doi.org/10.1038/35085068
  20. Meda L, Cassatella MA, Szendrei GI, Otvos L Jr, Baron P, Villalba M, et al. : Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374 : 647-650, 1995 https://doi.org/10.1038/374647a0
  21. Monforte R, Estruch R, Valls-Solé J, Nicolás J, Villalta J, Urbano-Marquez A : Autonomic and peripheral neuropathies in patients with chronic alcoholism. A dose-related toxic effect of alcohol. Arch Neurol 52 : 45-51, 1995 https://doi.org/10.1001/archneur.1995.00540250049012
  22. Naik AK, Tandan SK, Dudhgaonkar SP, Jadhav SH, Kataria M, Prakash VR, et al. : Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J Pain 10 : 573-579, 2006 https://doi.org/10.1016/j.ejpain.2005.08.006
  23. Narita M, Miyoshi K, Narita M, Suzuki T : Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. Neurosci Lett 414 : 21-25, 2007 https://doi.org/10.1016/j.neulet.2006.10.062
  24. Nikulina E, Tidwell JL, Dai HN, Bregman BS, Filbin MT : The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. Proc Natl Acad Sci U S A 101 : 8786-8790, 2004 https://doi.org/10.1073/pnas.0402595101
  25. Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT,et al. : cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med 10 : 610-616, 2004 https://doi.org/10.1038/nm1056
  26. Pentney RJ, Quackenbush LJ : Dendritic hypertrophy in Purkinje neurons of old Fischer 344 rats after long-term ethanol treatment. Alcohol Clin Exp Res 14 : 878-886, 1990 https://doi.org/10.1111/j.1530-0277.1990.tb01831.x
  27. Schaal SM, Golshani R, Ghosh M, Lovera L, Lopez M, Patel M, et al. : Targeting phosphodiesterase-4 after spinal cord injury using pharmacological and molecular approches. J Neurotrauma 25 : 297, 2008
  28. Sharma SS, Sayyed SG : Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy. Clin Exp Pharmacol Physiol 33 : 1022-1028, 2006 https://doi.org/10.1111/j.1440-1681.2006.04481.x
  29. Soares HD, Hicks RR, Smith D, McIntosh TK : Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci 15 : 8223-8233, 1995
  30. Tanaka M, Sotomatsu A, Yoshida T, Hirai S, Nishida A : Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death. J Neurochem 63 : 266-270, 1994
  31. Verghese MW, McConnell RT, Strickland AB, Gooding RC, Stimpson SA, Yarnall DP, et al. : Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors. J Pharmacol Exp Ther 272 : 1313-1320, 1995
  32. Victor M : Polyneuropathy due to nutritional deficiency and alcoholism in Dyke PJ, Thomas PK, Lambert EH (eds) : Peripheral neuropathy. Philadelphia : WB Saunders Co, 1975, pp1030-1066
  33. Vitarbo EA, Chatzipanteli K, Kinoshita K, Truettner JS, Alonso OF, Dietrich WD : Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats : the effect of injury severity and brain temperature. Neurosurgery 55 : 416-424; discussion 424-425, 2004 https://doi.org/10.1227/01.NEU.0000130036.52521.2C
  34. Yerdelen D, Koc F, Uysal H : Strength-duration properties of sensory and motor axons in alcoholic polyneuropathy. Neurol Res 30 : 746-750, 2008 https://doi.org/10.1179/174313208X291694
  35. Zou J, Rabin RA, Pentney RJ : Ethanol enhances neurite outgrowth in primary cultures of rat cerebellar macroneurons. Brain Res Dev Brain Res 72 : 75-84, 1993 https://doi.org/10.1016/0165-3806(93)90161-3

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