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  • 제12권3호
  • /
  • Pages.126-128
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  • 2012
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma

  • Kim, Young-Woon (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Ka-Young (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Su-Hyun (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Chung, Yoon-Yung (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Yahng, Seung-Ah (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Sung-Eun (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Park, Gyeong-Sin (Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Min, Chang-Ki (Division of Hematology, Department Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 투고 : 2012.04.23
  • 심사 : 2012.05.24
  • 발행 : 2012.06.30
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초록

We report on a case of severe hepatotoxicity in a 52-year-old male with multiple myeloma (MM) who had received bortezomib therapy. At patient presentation, liver enzymes were normal, but started to markedly increase 3 days after the patient's second dose of bortezomib was administered, when free kappa light chains were noticeably reduced in the serum. After discontinuation of bortezomib, liver enzymes recovered gradually to baseline. Then, the patient was started on a thalidomide-containing regimen, which he was able to tolerate well. The patient achieved complete remission prior to autologous stem cell transplantation (ASCT). The patient underwent ASCT without occurrence of further liver toxicity.

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참고문헌

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  4. Karin, M. and A. Lin. 2002. NF-kappaB at the crossroads of life and death. Nat. Immunol. 3: 221-227.
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  6. Ghobrial, I. M. and S. V. Rajkumar. 2003. Management of thalidomide toxicity. J. Support. Oncol. 1: 194-205.

피인용 문헌

  1. Boronic Acid-Containing Proteasome Inhibitors: Alert to Potential Pharmaceutical Bioactivation vol.26, pp.4, 2012, https://doi.org/10.1021/tx400032n
  2. The use of novel agents in multiple myeloma patients with hepatic impairment vol.11, pp.3, 2015, https://doi.org/10.2217/fon.14.270
  3. Injury pattern recognition to discriminate competing causes of liver injury vol.39, pp.5, 2012, https://doi.org/10.1111/liv.14056