IMMUNE NETWORK

  • 제12권2호
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  • Pages.48-57
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  • 2012
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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The Roles and Perspectives of Toll-Like Receptors and $CD4^+$ Helper T Cell Subsets in Acute Viral Encephalitis

  • Han, Young-Woo (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Singh, Sunit K. (Laboratory of Neurovirology and Inflammation Biology, Centre for Cellular and Molecular Biology) ;
  • Eo, Seong-Kug (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University)
  • 투고 : 2012.02.03
  • 심사 : 2012.02.22
  • 발행 : 2012.04.30
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초록

Acute viral encephalitis caused by neurotrophic viruses, such as mosquito-borne flaviviruses, is an emerging and re-emerging disease that represents an immense global health problem. Considerable progression has been made in understanding the pathogenesis of acute viral encephalitis, but the immune-pathological processes occurring during the progression of encephalitis and the roles played by various molecules and cellular components of the innate and adaptive systems still remain undefined. Recent findings reveal the significant contribution of Toll-like receptors (TLRs) and regulatory $CD4^+$ T cells in the outcomes of infectious diseases caused by neurotrophic viruses. In this review, we discuss the ample evidence focused on the roles of TLRs and $CD4^+$ helper T cell subsets on the progression of acute viral encephalitis. Finally, we draw attention to the importance of these molecules and cellular components in defining the pathogenesis of acute viral encephalitis, thereby providing new therapeutic avenues for this disease.

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참고문헌

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