Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The Effects of Triallelic Serotonin Transporter Gene Polymorphism and Stressful Life Event on Depression in Patients with Alcohol Dependence

알코올 의존 환자에서 삼대립 세로토닌 수송체 유전자 다형성과 생활사건 스트레스가 우울증에 미치는 영향

  • Jang, Hyun-Chung (Department of Psychiatry, Chungbuk National University College of Medicine) ;
  • Lee, Sang-Ick (Department of Psychiatry, Chungbuk National University College of Medicine) ;
  • Kim, Sie-Kyeong (Department of Psychiatry, Chungbuk National University College of Medicine) ;
  • Shin, Chul-Jin (Department of Psychiatry, Chungbuk National University College of Medicine) ;
  • Son, Jung-Woo (Department of Psychiatry, Chungbuk National University College of Medicine) ;
  • Ju, Ga-Won (Department of Psychiatry, Chungbuk National University College of Medicine) ;
  • Park, Jae-Young (Department of Psychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Jee, Kyung-Hwan (Our-Town Psychiatric Clinic) ;
  • Lee, Sang-Gu (Yesarang Hospital)
  • 장현정 (충북대학교 의과대학 정신건강의학교실) ;
  • 이상익 (충북대학교 의과대학 정신건강의학교실) ;
  • 김시경 (충북대학교 의과대학 정신건강의학교실) ;
  • 신철진 (충북대학교 의과대학 정신건강의학교실) ;
  • 손정우 (충북대학교 의과대학 정신건강의학교실) ;
  • 주가원 (충북대학교 의과대학 정신건강의학교실) ;
  • 박재영 (서울대학교 의과대학 분당서울대학교병원 정신건강의학교실) ;
  • 지경환 (우리동네 정신건강의학과의원) ;
  • 이상구 (예사랑 병원)
  • Received : 2012.01.25
  • Accepted : 2012.05.09
  • Published : 2012.05.31
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Abstract

Objectives : The purpose of this study is to investigate the relationship between the triallelic serotonin transporter gene and stressful life events to determine their effect on depression with alcohol dependence. Methods : Ninety-five hospitalized patients with alcohol dependence (73 male, 22 female) were enrolled in this study. Thirty-two (33.7%) of the total patients were diagnosed with major depressive disorder and dysthymic disorder by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV. The characteristics of stress were evaluated using the stressful life events scale, and depressive symptoms were assessed using the depression scale (Beck Depression Inventory, BDI). Alcoholism with depression (n = 32) and alcoholism without depression (n = 63) were genotyped for the triallelic serotonin transporter gene ($L_A$ : higher expressing allele, $L_G$/S : lower expressing allele). Results : There was no significant difference in the allele frequency between the depression group and the non-depression group (${\chi}^2$ = 0.345, p = 0.619). $L_G$/S alleles had more comorbid depression in the higher score of stressful life events scale [Mental-Haenszel (MH)-${\chi}^2$ = 4.477, p = 0.034]. But there was no significant difference in the comorbidity according to the scores from the stressful life event scale in the $L_A$ alleles (MH-${\chi}^2$ = 0.741, p = 0.399). In the results, alcohol-dependent individuals with $L_G$/S alleles had more comorbid depression than those with $L_A$ alleles when they had experienced severe stressful life events (MH-odds ratio = 2.699, p = 0.028). Conclusions : These results suggest that there is no direct relationship between triallelic serotonin transporter gene and depression in the alcohol dependent patients. But alcohol dependent individuals with the lower expressing alleles of the serotonin transporter gene were more susceptible to depression than those with the higher expressing alleles in response to stressful life events.

Keywords

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