생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제19권3호
  • /
  • Pages.115-120
  • /
  • 2012
  • /
  • 1225-8709(pISSN)
  • /
  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

조현병 환자의 인지기능과 뇌 사건유발전위의 관계

Cognitive Abilities and Auditory Event Related Potentials in Patients with Schizophrenia

  • 김가영 (가톨릭대학교 의과대학 정신건강의학교실) ;
  • 민정아 (가톨릭대학교 의과대학 정신건강의학교실) ;
  • 채정호 (가톨릭대학교 의과대학 정신건강의학교실)
  • Kim, Ka-Young (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Min, Jung-Ah (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Chae, Jeong-Ho (Department of Psychiatry, College of Medicine, The Catholic University of Korea)
  • 투고 : 2011.09.22
  • 심사 : 2012.05.02
  • 발행 : 2012.08.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : Event-related potentials have been suggested as an objective marker for brain functions in psychiatric disorders. This study was aimed to investigate the relationships between P300, the mismatch negativity (MMN), the loudness dependence of the auditory evoked potential (LDAEP), demographic and clinical variables including neurocognitive abilities in patients with schizophrenia. Methods : P300, the MMN, and the LDAEP were measured and the Korean Stroop color-word test (K-stroop test) and the Wisconsin Card Sorting Test (WCST) were performed in 43 patients with schizophrenia. The relationship of the latency and amplitude of P300 and the MMN as well as regression slope of the LDAEP with demographic and clinical variables were analyzed by t-test and correlation analyses for categorical and continuous variables, respectively. Results : After controlling for age, the latency of central (Cz) and parietal (Pz) P300 posivitively correlated with GAF at admission (Cz ; ${\gamma}$ = 0.385, p = 0.047, Pz ; ${\gamma}$ = 0.421, p = 0.029). The amplitude of parietal P300 correlated with the correction rate of the K-stroop test (${\gamma}$ = 0.575, p = 0.002). In addition, the frontal (Fz) P300 latency tended to negatively correlated with the correction rate of the WCST (${\gamma}$ = -0.371, p = 0.057). Conclusions : Our findings suggest that the values of P300 latency and amplitude might be correlated with GAF at admission and working memory measured by the K-Stroop test and the WCST. Meanwhile, the MMN and the LDAEP did not correlate with demographic and clinical variables. These results support the results of previous studies showing associations with P300 and impaired cognitive ability.

키워드

참고문헌

  1. Homayoun S, Nadeau-Marcotte F, Luck D, Stip E. Subjective and objective cognitive dysfunction in schizophrenia-is there a link? Front Psychol 2011;2:148.
  2. King FA. Handbook of Behavioral Neurobiology. New York: Plenum Press;1978. p.345-363.
  3. Ford JM, Mathalon DH, Marsh L, Faustman WO, Harris D, Hoff AL, et al. P300 amplitude is related to clinical state in severely and moderately ill patients with schizophrenia. Biol Psychiatry 1999;46:94-101. https://doi.org/10.1016/S0006-3223(98)00290-X
  4. Walhovd KB, Fjell AM. The relationship between P3 and neuropsychological function in an adult life span sample. Biol Psychol 2003;62:65-87. https://doi.org/10.1016/S0301-0511(02)00093-5
  5. Jausovec N, Jausovec K. Correlations between ERP parameters and intelligence: a reconsideration. Biol Psychol 2000;55:137-154. https://doi.org/10.1016/S0301-0511(00)00076-4
  6. McCarley RW, Faux SF, Shenton ME, Nestor PG, Adams J. Event-related potentials in schizophrenia: their biological and clinical correlates and a new model of schizophrenic pathophysiology. Schizophr Res 1991;4:209-231. https://doi.org/10.1016/0920-9964(91)90034-O
  7. Turetsky BI, Colbath EA, Gur RE. P300 subcomponent abnormalities in schizophrenia: I. Physiological evidence for gender and subtype specific differences in regional pathology. Biol Psychiatry 1998;43:84-96. https://doi.org/10.1016/S0006-3223(97)00258-8
  8. Coburn KL, Shillcutt SD, Tucker KA, Estes KM, Brin FB, Merai P, et al. P300 delay and attenuation in schizophrenia: reversal by neuroleptic medication. Biol Psychiatry 1998;44:466-474. https://doi.org/10.1016/S0006-3223(97)00402-2
  9. Kok A. On the utility of P3 amplitude as a measure of processing capacity. Psychophysiology 2001;38:557-577. https://doi.org/10.1017/S0048577201990559
  10. Gaspar PA, Ruiz S, Zamorano F, Altayo M, Perez C, Bosman CA, et al. P300 amplitude is insensitive to working memory load in schizophrenia. BMC Psychiatry 2011;11:29. https://doi.org/10.1186/1471-244X-11-29
  11. Linden DE. The p300: where in the brain is it produced and what does it tell us? Neuroscientist 2005;11:563-576. https://doi.org/10.1177/1073858405280524
  12. Naatanen R, Escera C. Mismatch negativity: clinical and other applications. Audiol Neurootol 2000;5:105-110. https://doi.org/10.1159/000013874
  13. Winkler I, Reinikainen K, Naatanen R. Event-related brain potentials reflect traces of echoic memory in humans. Percept Psychophys 1993;53:443-449. https://doi.org/10.3758/BF03206788
  14. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med 1992;327:604-612. https://doi.org/10.1056/NEJM199208273270905
  15. Juckel G, Gudlowski Y, Muller D, Ozgurdal S, Brune M, Gallinat J, et al. Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study. Psychiatry Res 2008;158:79-82. https://doi.org/10.1016/j.psychres.2007.08.013
  16. Ngan ET, Yatham LN, Ruth TJ, Liddle PF. Decreased serotonin 2A receptor densities in neuroleptic-naive patients with schizophrenia: A PET study using [(18)F]setoperone. Am J Psychiatry 2000;157:1016-1018. https://doi.org/10.1176/appi.ajp.157.6.1016
  17. American Psychiatric Association. Diagnostic criteria from DSM-IV-TR. Washington, D.C.: American Psychiatric Association;2000. p.297-316.
  18. Yang E, Kim JH, Lee SH. Smoking behavior and loudness dependence of the auditory evoked potential among male patients with major depressive disorder. Korean J Psychopharmacol 2011;22:89-95.
  19. Polich J, Howard L, Starr A. Effects of age on the P300 component of the event-related potential from auditory stimuli: peak definition, variation, and measurement. J Gerontol 1985;40:721-726. https://doi.org/10.1093/geronj/40.6.721
  20. Polich J, Howard L, Starr A. P300 latency correlates with digit span. Psychophysiology 1983;20:665-669. https://doi.org/10.1111/j.1469-8986.1983.tb00936.x
  21. Duncan-Johnson CC, Kopell BS. The Stroop effect: brain potentials localize the source of interference. Science 1981;214:938-940. https://doi.org/10.1126/science.7302571
  22. Dichter GS, van der Stelt O, Boch JL, Belger A. Relations among intelligence, executive function, and P300 event related potentials in schizophrenia. J Nerv Ment Dis 2006;194:179-187. https://doi.org/10.1097/01.nmd.0000202490.97425.de
  23. Ford JM, Pfefferbaum A, Roth W. P3 and schizophrenia. Ann N Y Acad Sci 1992;658:146-162. https://doi.org/10.1111/j.1749-6632.1992.tb22843.x
  24. Iwanami A, Okajima Y, Kuwakado D, Isono H, Kasai K, Hata A, et al. Event-related potentials and thought disorder in schizophrenia. Schizophr Res 2000;42:187-191. https://doi.org/10.1016/S0920-9964(99)00132-2
  25. Mathalon DH, Ford JM, Rosenbloom M, Pfefferbaum A. P300 reduction and prolongation with illness duration in schizophrenia. Biol Psychiatry 2000;47:413-427. https://doi.org/10.1016/S0006-3223(99)00151-1
  26. Mathalon DH, Ford JM, Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biol Psychiatry 2000;47:434-449. https://doi.org/10.1016/S0006-3223(99)00277-2
  27. Ilan AB, Polich J. P300 and response time from a manual Stroop task. Clin Neurophysiol 1999;110:367-373. https://doi.org/10.1016/S0168-5597(98)00053-7
  28. Wickens C, Kramer A, Vanasse L, Donchin E. Performance of concurrent tasks: a psychophysiological analysis of the reciprocity of information-processing resources. Science 1983;221:1080-1082. https://doi.org/10.1126/science.6879207
  29. Rossi A, Daneluzzo E, Mattei P, Bustini M, Casacchia M, Stratta P. Wisconsin card sorting test and Stroop test performance in schizophrenia: a shared construct. Neurosci Lett 1997;226:87-90. https://doi.org/10.1016/S0304-3940(97)00253-X
  30. Yu YW, Chen TJ, Chen MC, Tsai SJ, Lee TW. Effect of age and global function score on schizophrenic p300 characteristics. Neuropsychobiology 2005;51:45-52. https://doi.org/10.1159/000082855
  31. Pallanti S, Quercioli L, Pazzagli A. Relapse in young paranoid schizophrenic patients: a prospective study of stressful life events, P300 measures, and coping. Am J Psychiatry 1997;154:792-798. https://doi.org/10.1176/ajp.154.6.792
  32. Hegerl U, Juckel G, Muller-Schubert A, Pietzcker A, Gaebel W. Schizophrenics with small P300: a subgroup with a neurodevelopmental disturbance and a high risk for tardive dyskinesia? Acta Psychiatr Scand 1995;91:120-125. https://doi.org/10.1111/j.1600-0447.1995.tb09751.x
  33. Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 1992;49:538-544. https://doi.org/10.1001/archpsyc.1992.01820070032005
  34. Huntley GW, Vickers JC, Morrison JH. Cellular and synaptic localization of NMDA and non-NMDA receptor subunits in neocortex: organizational features related to cortical circuitry, function and disease. Trends Neurosci 1994;17:536-543. https://doi.org/10.1016/0166-2236(94)90158-9
  35. Javitt DC, Steinschneider M, Schroeder CE, Arezzo JC. Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia. Proc Natl Acad Sci U S A 1996;93:11962-11967. https://doi.org/10.1073/pnas.93.21.11962
  36. Oades RD, Dittmann-Balcar A, Zerbin D, Grzella I. Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive-compulsive disorder and healthy subjects. Biol Psychiatry 1997;41:1196-1210. https://doi.org/10.1016/S0006-3223(96)00214-4
  37. Baldeweg T, Klugman A, Gruzelier J, Hirsch SR. Mismatch negativity potentials and cognitive impairment in schizophrenia. Schizophr Res 2004;69:203-217. https://doi.org/10.1016/j.schres.2003.09.009
  38. Mihailescu S, Palomero-Rivero M, Meade-Huerta P, Maza-Flores A, Drucker-Colin R. Effects of nicotine and mecamylamine on rat dorsal raphe neurons. Eur J Pharmacol 1998;360:31-36. https://doi.org/10.1016/S0014-2999(98)00658-X
  39. Park YM, Lee SH, Kim S, Bae SM. The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:313-316. https://doi.org/10.1016/j.pnpbp.2009.12.004