DOI QR코드

DOI QR Code

Effects of Combined Exercise on Body Composition, Blood Lipids, and BDNF in Obese Adolescents

복합운동이 과체중 및 비만청소년의 신체구성, 혈중지질 및 BDNF에 미치는 영향

  • 신석민 (경남대학교 체육교육과) ;
  • 김철형 (경남대학교 체육교육과)
  • Received : 2012.07.26
  • Accepted : 2012.08.18
  • Published : 2012.09.30

Abstract

Exercise leads to the release of certain neurotransmitters in the brain that alleviate pain, both physical and mental. The purpose of this study was to investigate effects of combined exercise on body composition, blood lipids, and brain-derived neurotrophic factor (BDNF) in overweight and obese adolescents. The subjects of this study were 18 boys who were divided into a combined exercise group (EG: n=9) and a control group (CG: n=9). The combined exercise program required exercise 50-60 minutes per day, three times a week, for 12 weeks. The results of the comparative analysis are as follows: The between-group comparison of the difference in the means before and after the intervention revealed a significant decrease in the EG compared with the CG: weight (p<0.01), BMI (p<0.05), %fat (p<0.05), fat mass (p<0.01). The %LBM of the EG showed a more significant increase (p<0.05) compared with the CG. The TC, LDL-C, and BDNF were not different between the EG and the CG. However, the TC and the LDL-C were decreased more in the EG than in the CG. The BDNF was increased more in the EG than in the CG. In conclusion, the combined exercise improved body composition but did not affect serum lipids or the BDNF.

비만은 여러 가지 질환을 유발하는데 이중에서도 뇌신경세포의 활성 및 생성에도 부정적인 영향을 미치는 것으로 보고되고 있어 이에 대한 추가적인 연구가 필요하다. 본 연구는 과체중 및 비만 청소년의 BDNF 개선을 위한 운동 효과를 검증하고자 12주 복합운동에 따른 신체구성, 혈중지질, BDNF의 변화를 분석하였다. 이를 위해 과체중 및 비만 청소년 18명을 복합운동군 9명, 대조군 9명으로 무선표집하여 연구를 진행하였다. 연구 결과 통계적으로 집단간 차이를 보이며 체중(p<0.01), BMI (p<0.05), 체지방률(p<0.05), 체지방량(p<0.01)이 감소하고, 제지방률(p<0.05)이 증가하였다. 또한 TC와 LDL-C의 평균은 운동군이 대조군보다 더 많은 감소 경향을 나타내었고, HDL-C는 두 집단 모두 감소하는 경향을 보였으나 모두 집단간 차이는 나타나지 않았다. 또한 BDNF의 평균은 운동군이 대조군보다 더 많은 증가 경향을 나타내었으나 집단간 차이는 나타나지 않았다. 본 연구를 통하여 12주 복합운동 프로그램은 과체중 및 비만 남자 청소년의 체중, BMI, 체지방률, 체지방량, 제지방률은 개선시킬 수 있으나 혈중 지질 및 BDNF의 변화에는 영향을 미치지 못하는 것을 알 수 있었다. 본 연구를 통하여 12주 복합운동 프로그램은 과체중 및 비만 남자 청소년의 체중, BMI, 체지방률, 체지방량, 제지방률은 개선시킬 수 있으나 혈중 지질 및 BDNF의 변화에는 영향을 미치지 못하는 것을 알 수 있었다.

Keywords

References

  1. Areeg, H., El-Gharbawy, D. C., Adler-Wailes, M. C., Mirch, K. R., Theim, L. R., Marian, T. and Jack, A. Y. 2006. Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. J. Clin. Endocr. Metab. 91, 3548-3552. https://doi.org/10.1210/jc.2006-0658
  2. Bray, G. A., Bouchard, C. and James, W. P. 1998. Handbook of obesity. New York: Marcel Dekker.
  3. Chan. K. L., Tong, K. Y. and Yip, S. P. 2008. Relationship of serum brain-derived neurotrophic factor and health-related lifestyle in healty human subjects. Neurosci. Lett. 447, 124-128. https://doi.org/10.1016/j.neulet.2008.10.013
  4. Choi, C. K. and Lee, Y. S. 2004. The effects of aerobic and aerobic combined with resistance exercise on the changes of blood lipid profiles, serum leptin and insulin in obese middle-school students boys. Korean J. Phy. Edu. 43, 579-588.
  5. Choi, S. H., Jo, M. W. and Shin, D. S. 2004. Effects of the 8-week resistance exercise on body composition, serum hormone profiles and feeding patterns of obese females. Korean J. Exer. Nutr. 37, 888-898.
  6. Consitt, L. A., Copeland, J. L. and Tremblay, M. S. 2001. Hormone responses to resistance vs endurance exercise in premenopausal females. J. Appl. Physiol. 26, 574-587. https://doi.org/10.1139/h01-032
  7. Diets, W. H. 1993. Therapeutic strategies in childhood obesity. Horm. Res. 39, 86-90. https://doi.org/10.1159/000182791
  8. Durstine, J. L., Grandjean, P. W., Cox, C. A. and Thompson, P. D. 2002. Lipid, lipoproteins and exercise. J. Cardiopulm Rehabil. 22, 385-398. https://doi.org/10.1097/00008483-200211000-00002
  9. Gaesser, G. A. and Rich, R. G. 1984. Effect of high and low-intensity exercise training on aerobic capacity and blood lipids. Med. Sci. Sports Exerc. 16, 269-275.
  10. Hill, R. D., Storandt, M. and Malley, M. 1993. The impact of long-term exercise training on psychological function in older adults. J. Gerontol. 48, 12-17. https://doi.org/10.1093/geronj/48.1.P12
  11. Hotamisgil, G. S. 2000. Molecular mechanisms of insulin resistance and role of the adipocyte. Int. J. Obes. Relat. Metab. Disord. 24, S23-27.
  12. Katzmarzyk, T., Leon, S. and Rankinen, T. 2001. Changes in blood lipids consequent to aerobic exercise training related to changes in body fat-ness and aerobic fitness. Metabolism 50, 841-848. https://doi.org/10.1053/meta.2001.24190
  13. Kim, J. S., Cho, H. C. and Kang, H. S. 2011. Effect of twelve weeks combined exercise on cytokine in relation to body fat in obese adolescents. Korean J. Exerc. Sci. 20, 332-338.
  14. Kim, S. H. and Youn, Y. B. 2011. Effects of combined exercise training on abdominal fat and adipokine in abdominal obese women. Korean J. Sport Sci. 20, 979-992.
  15. Kubitz, K. A. and Mott, A. A. 1996. EEG wer spectral densities during and after cycle ergometer exercise. Res. Q. Exerc. Sport 67, 91-96. https://doi.org/10.1080/02701367.1996.10607929
  16. Kwon, J. H. and Lee, J. K. 2009. Effect on the change in body composition, blood pressure and risk factors for CAD (coronary artery disease) of combined exercise in the middle-aged obese women during 16 weeks. Korean J. Sport Sci. 18, 1253-1263.
  17. Malina, R. M., Bouchard, C. and Bar-Or, O. 2004. Growth, maturation and physical activity. (2nd Ed.). Champaingn, IL: Human Kinetics.
  18. Moon, J. S., Lee, S. Y., Nam, C. M., Choi, J., Choe, B., Seo, J., Oh, K., Jang, M., Hwang, S., Yoo, M. H., Kim, Y. T. and Lee, C. G. 2008. Korean J. Pediatr. 51, 1-25. https://doi.org/10.3345/kjp.2008.51.1.1
  19. Morrison, J. A., Sprecher, D., McMahon, R. P., Simon, J., Schreiber, G. B. and Khoury, P. R. 1996. Obesity and high-density lipoprotein cholesterol in black and white 9-and 10-year-old girls: The national heart, lung, and blood institute growth and health study. Metabolism 45, 469-474. https://doi.org/10.1016/S0026-0495(96)90221-8
  20. Motoyama, M., Sunami, Y., Kinoshita, F., Irie, T., Sasaki, J., Arakawa, K., Kiyonaga, A., Tanaka, H. and Shindo, M. 1995. The effects of long-term low intensity aerobic training and detraining on serum lipid and lipoprotein concentrations in elderly men and women. Eur. J. Appl. Physiol. Occup. Physiol. 70, 126-131. https://doi.org/10.1007/BF00361539
  21. Nakagawa, T., Ogawa, Y., Ebihara, K., Yamanaka, M., Tsuchida, A., Taiji, M., Noguchi, H. and Nakao, K. 2003. Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. Int. J. Obes. Relat. Metab. Disord. 27, 557-565. https://doi.org/10.1038/sj.ijo.0802265
  22. Neeper, S. A., Gumez-Pinilla, F., Choi, J. and Cotman, C. W. 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726, 49-56. https://doi.org/10.1016/0006-8993(96)00273-9
  23. Niti, M., Yap, K. B., Kua, E. H., Tan, C. H. and Ng, T. P. 2008. Physical, social and productive leisure activities, cognitive decline and interaction with APOE-epsilon 4 genotype in Chinese older adults. Int. Psychogeriatr. 20, 237-251.
  24. Park, H. S., Sim, S. J. and Park, J. Y. 2004. Effect of weight reduction on metabolic syndrome in Korean obese patients. J. Korean Med. Sci. 19, 202-208. https://doi.org/10.3346/jkms.2004.19.2.202
  25. Pencea, V., Bingaman, K. D., Wiegand, S. J. and Luskin, M. B. 2001. Infusion of brain derived neurotrophic factor into lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus and hypothalamus. J. Neurosci. 21, 6706-6717.
  26. Prabhakaran, B., Dowling, E. A., Brach, J. D., Wwain, D. P. and Leuthotz, B. C. 1999. Effect of 14 weeks of resistance training on lipid profile and body fat percentage in premenopausal women. Br. J. Sports Med. 33, 190-195. https://doi.org/10.1136/bjsm.33.3.190
  27. Pyeon, M. Y., Kwak, Y. S. and Kim, H. J. 2010. The effects of warming-up with resistance training on the body composition and physical fitness in children. J. Korean Data Analysis Society 12, 3477-3492.
  28. Pyeon, M. Y., Park, M. K. and Kim, H. J. 2011. Effects of resistance exercise on blood lipids and GH related factors in children. J. Sport and Leisure Studies 44, 803-816.
  29. Pyun, M. Y. and Kim, H. J. 2011. Physical fitness and brain electrocortical activity during learning process. J. Korean Data Analysis Society 13, 1751-1762.
  30. Rhodes, J. S., Susan, J., Isabelle, G., Gordon, S. M., Henriette van, P., Theodore, G. J. and Fred, H. G. 2003. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav. Neurosci. 117, 1006-1016. https://doi.org/10.1037/0735-7044.117.5.1006
  31. Rico, H., Arribas, I., Casanova, F. J., Duce, A. M., Hemandez, E. R. and Cortes-Prieto, J. 2002. Bone mass, bone metabolism, gonadal status and body mass index. Osteoporos. Int. 13, 379-387. https://doi.org/10.1007/s001980200043
  32. Russo-Neustadt, A., Ha, T., Ramirez, R. and Keslak, J. P. 2001. Physical activity antidepressant treatment combination: impact on brain derived neuro trophic factor and behavior in an animal model. Behav. Brain Res. 120, 87-95. https://doi.org/10.1016/S0166-4328(00)00364-8
  33. Seifert, T., Brassard, P., Wissenberg, M., Rasmussen, P., Nordby, P., Stalknecht, B., Adser, H., Jakobsen, A. H., Pilegaard, H., Nielsen, H. B. and Secher, N. H. 2010. Endurance training enhances BDNF release from the human brain. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, 372-377. https://doi.org/10.1152/ajpregu.00525.2009
  34. Sofi, F., Valecchi, D., Bacci, D., Abbate, R., Gensini, G. F. and Casini, A. 2011. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J. Intern. Med. 269, 107-117. https://doi.org/10.1111/j.1365-2796.2010.02281.x
  35. Stefanick, L., Mackey, S., Sheehan, M., Ellsworth, N., Haskell, L. and Wood, D. 1998. Effects of diet and exercise un men and post-menopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. N. Engl. J. Med. 339, 12-20. https://doi.org/10.1056/NEJM199807023390103
  36. Stein, R. A., Michielli, D. W., Glantz, M. D., Sardy, H., Cohen, A., Goldberg, N. and Brown, C. D. 1990. Effects of different exercise training intensities on lipoprotein cholesterol fractions in healthy middle-aged men. Am. Heart J. 119, 277-283. https://doi.org/10.1016/S0002-8703(05)80017-1
  37. Swift, D. L., Johannsen, N. M., Myers, V. H., Earnest, C. P., Smits, J. A. J., Blair, S. N. and Church, T. S. 2012. The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with Type 2 diabetes. PLoS One 7, 1-7.
  38. Tang, S. W., Chu, E., Hui, T., Helmeste, D. and Law, C. 2008. Influence ofexercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neurosci. Lett. 431, 62-65. https://doi.org/10.1016/j.neulet.2007.11.019
  39. Titterness, A. K., Wiebe, E., Kwasnica, A., Keyes, G. and Christie, B. R. 2011. Voluntary exercise does not enhance long-term potentiation in the adolescent female dentate gyrus. Neuroscience 183, 25-31. https://doi.org/10.1016/j.neuroscience.2011.03.050
  40. Zoladz, J. A., Pilc, A., Majerczak, J., Grandys, M., Zapart-Bukowska, J. and Duda, K. 2008. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J. Physiol. Pharmacol. 59, 119-132.

Cited by

  1. Effects of Complex Exercise Program on Body Composition of Dormitory-type Middle School Students vol.3, pp.2, 2015, https://doi.org/10.15268/ksim.2015.3.2.017