DOI QR코드

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Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

  • Chang, Hoo-Sun (Department of Preventive Medicine, Yonsei University) ;
  • Park, Eun-Cheol (Department of Preventive Medicine, Yonsei University) ;
  • Chung, Woo-Jin (Institute of Health Services Research, Yonsei University) ;
  • Nam, Chung-Mo (Department of Preventive Medicine, Yonsei University) ;
  • Choi, Kui-Son (National Cancer Control Research Institute, National Cancer Center) ;
  • Cho, Eun (Department of Preventive Medicine, Yonsei University) ;
  • Cho, Woo-Hyun (Department of Preventive Medicine, Yonsei University)
  • 발행 : 2012.06.30

초록

Background: There are limited data evaluating the cost-effectiveness of gastric cancer screening using endoscopy or upper gastrointestinal x-ray in the general population. Objective: To evaluate the cost-effectiveness of population-based screening for gastric cancer in South Korea by decision analysis. Methods: A time-dependent Markov model for gastric cancer was constructed for healthy adults 30 years of age and older, and a deterministic sensitivity analysis was performed. Cost-utility analysis with multiple strategies was conducted to compare the costs and effects of 13 different screening alternatives with respect to the following eligibility criteria: age at the beginning of screening, screening interval, and screening method. The main outcome measurement was the incremental cost-effectiveness ratio. Results: The results revealed that annual endoscopic screening from ages 50-80 was the most cost-effective for the male population. In the females, biennial endoscopy screening from ages 50-80 was calculated as the most cost-effective strategy among the 12 screening alternatives. The most cost-effective screening strategy may be adjustable according to the screening costs and the distribution of cancer stage at screening. The limitation was that effectiveness data were obtained from published sources. Conclusions: Using the threshold of $19,162 per quality-adjusted life year on the basis of the Korean gross domestic product (2008), as suggested by the World Health Organization, endoscopic gastric cancer screening starting at the age of 50 years was highly cost-effective in the Korean population. The national recommendation for gastric cancer screening should consider the starting age of screening, the screening interval, and the screening modality.

키워드

참고문헌

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피인용 문헌

  1. Cost-effectiveness Outcomes of the National Gastric Cancer Screening Program in South Korea vol.14, pp.4, 2013, https://doi.org/10.7314/APJCP.2013.14.5.2533
  2. A Cost-Effectiveness Analysis Evaluating Endoscopic Surveillance for Gastric Cancer for Populations with Low to Intermediate Risk vol.8, pp.12, 2013, https://doi.org/10.1371/journal.pone.0083959
  3. Risk of Lymph Node Metastases from Early Gastric Cancer in Relation to Depth of Invasion: Experience in a Single Institution vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5371
  4. The Korean guideline for gastric cancer screening vol.58, pp.5, 2015, https://doi.org/10.5124/jkma.2015.58.5.373
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  6. Determining the cost-effectiveness of endoscopic surveillance for gastric cancer in patients with precancerous lesions vol.12, pp.4, 2016, https://doi.org/10.1111/ajco.12569
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