한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제29권4호
  • /
  • Pages.356-359
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  • 2012
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

개의 위에서 발생한 골수외 형질세포종

Gastric Extramedullary Plasmacytoma in a Dog

  • 심사 : 2012.08.22
  • 발행 : 2012.08.30
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초록

암컷, 8년령, 3.2 kg의 시츄견이 간헐적인 구토를 주증으로 내원하였다. 기본 혈액검사 및 방사선 검사에서 특별한 이상 소견은 관찰되지 않았다. 복부 초음파 검사에서 위벽에서 유래한 것으로 생각되는 저에코의 둥근 종괴가 관찰되었다. 위 내시경 검사에서 둥근 종괴가 유문동 벽에서 내강으로 돌출되어 있고, 종괴 및 주변 점막의 비정상적인 소견은 관찰되지 않았다. 이에 위 종괴 절제술을 실시하였고, 면역 염색을 포함한 조직학적 검사에서 extramedullary plasmacytoma로 진단되었다. 환자는 임상 증상이 개선되었으며, 약 2년 동안 재발 및 전이 소견 없이 건강한 상태이다.

An eight-year-old, spayed female Shih-tzu, weighing 3.2 kg with a history of chronic intermittent vomiting and unknown pain for four months was referred. In ultrasonography, a small round hypoechoic mass was identified in the gastric wall. Gastric endoscopy showed a solitary raised mass with smooth surface in the pyloric antrum. Surgical resection was performed. Histopathologic findings with immunohistochemical studies showed extramedullary plasmacytoma in the gastric submucosal and muscle wall layer. The patient recovered normally without any complications. The tumor has not been re-occurred after surgical removal, to date.

키워드

참고문헌

  1. Aoki M, Kim T, Shimada T, Kuwamura M, Yamate J, Ohashi F. A primary hepatic plasma cell tumor in a dog. J Vet Med Sci 2004; 66: 445-447. https://doi.org/10.1292/jvms.66.445
  2. Baer KE, Patnaik AK, Gilbertson SR, Hurvitz AI. Cutaneous plasmacytomas in dogs: A morphologic and immunohistochemical study. Vet Pathol 1989; 26: 216-221. https://doi.org/10.1177/030098588902600305
  3. Breuer W, Colbatzky F, Platz S, Hermanns W. Immunoglobulin- producing tumours in dogs and cats. J Comp Pathol 1993; 109: 203-216. https://doi.org/10.1016/S0021-9975(08)80246-0
  4. Brunnert SR, Altman NH. Identification of immunoglobulin light chains in canine extramedullary plasmacytomas by thioflavine T and immunohistochemistry, J Vet Diagn Invest 1991; 3: 245-251. https://doi.org/10.1177/104063879100300312
  5. Brunnert SR, Dee LA, Herron AJ, Altman NH. Gastric extramedullary plasmacytoma in a dog. J Am Vet Med Assoc 1992; 200: 1501-1502.
  6. Cangul IT, Wunen M, van Garderen E, van den Ingh TS. Clinico-pathological aspects of canine cutaneous and mucocutaneous plamacytomas. J Vet Med A Physiol Pathol Clin Med 2002; 49: 307-312. https://doi.org/10.1046/j.1439-0442.2002.00456.x
  7. Chaffin K, Cross AR, Allen SW, Mahaffey EA, Watson SK. Extramedullary plasmacytoma in the trachea of a dog. J Am Vet Med Assoc 1998; 212: 1579-1581.
  8. Choi YK, Lee JY, Kim DY, Park JI, Jeong SW, Par HM, Park C. Uterine extramedullary plasmacytoma in a dog. Vet Rec 2004; 154: 699-700. https://doi.org/10.1136/vr.154.22.699
  9. Clark GN, Berg J, Engler SJ, Bronson RT. Extramedullary plasmacytomas in dogs: Results of surgical excision in 131 cases. J Am Anim Hosp Assoc 1992; 28: 105-111.
  10. Frazier KS, Hines ME, Hurvitz AI, Robinson PG, Herron AJ. Analysis of DNA aneuploidy and c-myc oncoprotein content of canine plasma cell tumors using flow cytometry. Vet Pathol 1993; 30: 505-511. https://doi.org/10.1177/030098589303000603
  11. Hamilton TA, Carpenter JL. Esophgeal plasmacytoma in a dog. J Am Vet Med Assoc 1994; 204: 1210-1211.
  12. Jackson MW, Helfand SC, Smedes SL, Bradley GA, Schultz RD. Primary IgG secreting plasma cell tumor in the gastrointestinal tract of a dog. J Am Vet Med Assoc 1994; 204: 404-406.
  13. Kupanoff PA, Popovitch CA, Goldschmidt MH. Colorectal plasmcytomas: a retrospective study of nine dogs. J Am Anim Hosp Assoc 2006; 42: 37-43.
  14. Kyriazidou A, Brown PJ, Lucke VM. An immunohistochemical study of cnine extramedullary plasma cell tumors. J Comp Pathol 1989; 100: 259-266. https://doi.org/10.1016/0021-9975(89)90103-5
  15. Lester SJ, Mesfin GM. A solitary plasmacytoma in a dog with progression to a disseminated myeloma. Can Vet J 1980; 21: 284-286.
  16. Lucke VM. Primary cutaneous plasmacytomas in the dog and cat. J Small Anim Pract 1987; 28: 49-55. https://doi.org/10.1111/j.1748-5827.1987.tb05970.x
  17. MacEwen EG, Patnaik AK, Hurvitz AI, Bradley R, Claypoole TF, Withrow SJ, Erlandson RA, Lieberman PH. Nonsecretory multiple myeloma in two dogs. J Am Vet Med Assoc 1984; 184: 1283-1286.
  18. MacEwen EG, Patnaik AK, Johnson GF, Hurvitz AI, Erlandson RA, Lieberman PH. Extramedullary plasmacytoma of the gastrointestinal tract in two dogs. J Am Vet Med Assoc 1984; 184: 1396-1398.
  19. Platz SJ, Breuer W, Pfleghaar S, Minkus G, Hermanns W. Prognostic value of histopathological grading in canine extramedullary plasmacytomas. Vet Pathol 1999; 36: 23-27. https://doi.org/10.1354/vp.36-1-23
  20. Rakich PM, Latimer KS, Weiss R, Steffens WL. Mucocutaneous plasmacytomas in dogs: 75 cases (1980-1987). J Am Vet Med Assoc 1989; 194: 803-810.
  21. Ramos-Vara JA, Miller MA, Valli VE. Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Vet Pathol 2007; 44: 875-884. https://doi.org/10.1354/vp.44-6-875
  22. Rowland PH, Valentine BA, Stebbins KE, Smith CA. Cutaneous plsmacytomas with amyloid in six dogs. Vet Pathol 1991; 28: 125-130. https://doi.org/10.1177/030098589102800204
  23. Trevor PB, Saunders GK, Waldron DR, Leib MS. Metatatic extramedullary plasmacytoma of the colon and rectum in a dog. J Am Vet Med Assoc 1993; 203: 406-409.
  24. Vail DM. Hematopoietic tumors In: Textbook of veterinary internal medicine. 7th ed. Philadelphia: Saunders. 2010; 2159- 2163.
  25. Withrow SJ, Vail DM. The pathology of neoplasia In: Small animal clinical oncology. 4th ed. Philadelphia: Saunders. 2007; 60-62.
  26. Withrow SJ, Vail DM. Hematopoietic tumors In: Small animal clinical oncology. 4th ed. Philadelphia: Saunders. 2007; 779-782
  27. Wright ZM, Rogers KS, Mansell J. Survival data for canine oral extramedullary plasmacytomas: a retrospective analysis (1996-2006). J Am Anim Hosp Assoc 2008; 44: 75-81.