References
- Berman DM, Karhadkar SS, Maitra A, et al (2003). Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 425, 846-51. https://doi.org/10.1038/nature01972
- Bijlsma MF, Spek CA, Zivkovic D, et al (2006). Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion. PLoS Biol, 4, e232. https://doi.org/10.1371/journal.pbio.0040232
- Chatel G, Ganeff C, Boussif N, et al (2007). Hedgehog signaling pathway is inactive in colorectal cancer cell lines. Int J Cancer, 121, 2622-7. https://doi.org/10.1002/ijc.22998
- Dessaud E, McMahon AP, Briscoe J (2008). Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogenregulated transcriptional network. Development, 135, 2489-503. https://doi.org/10.1242/dev.009324
- Douard R, Moutereau S, Pernet P, et al (2006). Sonic Hedgehogdependent proliferation in a series of patients with colorectal cancer. Surgery, 139, 665-70. https://doi.org/10.1016/j.surg.2005.10.012
- Echelard Y, Epstein DJ, St-Jacques B, et al (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell, 75, 1417-30. https://doi.org/10.1016/0092-8674(93)90627-3
- Evangelista M, Tian H, de Sauvage FJ (2006). The hedgehog signaling pathway in cancer. Clin Cancer Res, 12, 5924-8. https://doi.org/10.1158/1078-0432.CCR-06-1736
- Fu X, Yang X, Li J, et al (2010). Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers. Pathology, 42, 553-9. https://doi.org/10.3109/00313025.2010.508785
- Jemal A, Siegel R, Ward E, et al (2008). Cancer statistics, 2008. CA Cancer J Clin, 58, 71-96. https://doi.org/10.3322/CA.2007.0010
- Kim J, Park S, Nam BH (2011). The risk of colorectal cancer is associated with the frequency of meat consumption in a population-based cohort in Korea. Asian Pac J Cancer Prev, 12, 2371-6.
- Kimman M, Norman R, Jan S, Kingston D, Woodward M (2012). The burden of cancer in member countries of the Association of Southeast Asian Nations (ASEAN). Asian Pac J Cancer Prev, 13, 411-20. https://doi.org/10.7314/APJCP.2012.13.2.411
- Marigo V, Roberts DJ, Lee SM, et al (1995). Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Genomics, 28, 44-51. https://doi.org/10.1006/geno.1995.1104
- Ma X, Chen K, Huang S, et al (2005). Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis, 26, 1698-705. https://doi.org/10.1093/carcin/bgi130
- McMahon AP, Ingham PW, Tabin CJ (2003). Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol, 53, 1-114. https://doi.org/10.1016/S0070-2153(03)53002-2
- Monzo M, Moreno I, Artells R, et al (2006). Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients. Cancer Letters, 233, 117-23. https://doi.org/10.1016/j.canlet.2005.03.001
- Ohta M, Tateishi K, Kanai F, et al (2005). p53-Independent negative regulation of p21/cyclin-dependent kinaseinteracting protein 1 by the sonic hedgehog- gliomaassociated oncogene 1 pathway in gastric carcinoma cells. Cancer Res, 65, 10822-9. https://doi.org/10.1158/0008-5472.CAN-05-0777
- Park B, Lee HY, Choi KS, et al (2011). Cancer screening in Korea, 2010: results from the Korean National Cancer Screening Survey. Asian Pac J Cancer Prev, 12, 2123-8.
- Saqui-Salces M, Merchant JL (2010). Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta, 1803, 786-95. https://doi.org/10.1016/j.bbamcr.2010.03.008
- Scales SJ, de Sauvage FJ (2009). Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci, 30, 303-12. https://doi.org/10.1016/j.tips.2009.03.007
- Steg AD, Katre AA, Bevis KS et al (2012). Smoothened antagonists reverse taxane resistance in ovarian cancer. Mol Cancer Ther. [Epub ahead of print]
- Tapati M, Jennifer D, Ting S, et al (2011). Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res, 71, 1092-102. https://doi.org/10.1158/0008-5472.CAN-10-2315
- Varjosalo M, Taipale J (2008). Hedgehog: functions and mechanisms. Genes Dev, 22, 2454-72. https://doi.org/10.1101/gad.1693608
- Varnat F, Duquet A, Malerba M, et al (2009). Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med, 1, 338-51. https://doi.org/10.1002/emmm.200900039
- Yang Q, Shen SS, Zhou S et al (2012). STAT3 activation and aberrant ligand-dependent sonic hedgehog signaling in human pulmonary adenocarcinoma. Exp Mol Pathol. [Epub ahead of print]
- Yoshikawa K, Shimada M, Miyamoto H, et al (2009) Sonic hedgehog relates to colorectal carcinogenesis. J Gastroenterol, 44, 1113-7. https://doi.org/10.1007/s00535-009-0110-2
- You S, Zhou J, Chen S, et al (2010). PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer. Ups J Med Sci, 115, 169-75. https://doi.org/10.3109/03009731003668316
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