Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Effects of Pinocembrin on the Initiation and Promotion Stages of Rat Hepatocarcinogenesis

  • Punvittayagul, Charatda (Department of Biochemistry and Center for Innovation in Chemistry, Faculty of Medicine, Chiang Mai University) ;
  • Pompimon, Wilart (Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University) ;
  • Wanibuchi, Hideki (Department of Pathology, Osaka City University Medical School) ;
  • Fukushima, Shoji (Japan Bioassay Research Center) ;
  • Wongpoomchai, Rawiwan (Department of Biochemistry and Center for Innovation in Chemistry, Faculty of Medicine, Chiang Mai University)
  • Published : 2012.05.30
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Abstract

Pinocembrin (5, 7-dihydroxyflavanone) is a flavanone extracted from the rhizome of Boesenbergia pandurata. Our previous studies demonstrated that pinocembrin had no toxicity or mutagenicity in rats. We here evaluated its effects on the initiation and promotion stages in diethylnitrosamine-induced rat hepatocarcinogenesis, using short- and medium-term carcinogenicity tests. Micronucleated hepatocytes and liver glutathione-S-transferase placental form foci were used as end point markers. Pinocembrin was neither mutagenic nor carcinogenic in rat liver, and neither inhibited nor prevented micronucleus formation as well as GST-P positive foci formation induced by diethylnitrosamine. Interestingly, pinocembrin slightly increased the number of GST-P positive foci when given prior to diethylnitrosamine injection.

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References

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