Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China

  • Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Loh, Marie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) ;
  • Lv, Si-Han (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Huang, Wen-Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Xie, Yao (Department of Epidemiology, West China School of Public Health, Sichuan University) ;
  • Soong, Richie (Cancer Science Institute of Singapore, National University of Singapore) ;
  • Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)
  • Published : 2012.05.30
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Abstract

Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched case-control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). Conclusions: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.

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References

  1. Brooks PJ (1997). DNA damage, DNA repair, and alcohol toxicity--a review. Alcohol Clin Exp Res, 21, 1073-82.
  2. Capella G, Pera G, Sala N, et al (2008). DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the epic-eurgast study. Int J Epidemiol, 37, 1316-25. https://doi.org/10.1093/ije/dyn145
  3. Duarte MC, Colombo J, Rossit AR, et al (2005). Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. World J Gastroenterol, 11, 6593-600. https://doi.org/10.3748/wjg.v11.i42.6593
  4. Ferlay J, Shin H, Bray F, et al (2010). Globocan 2008 V1.2, Cancer Incidence and Mortality Worldwide: IARC Cancerbase No. 10 [Internet], Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr.
  5. Gao Y, Hu N, Han X, et al (2009). Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. Bmc Cancer, 9, 269.
  6. Gonzalez CA, Sala N, Capella G (2002). Genetic susceptibility and gastric cancer risk. Int J Cancer, 100, 249-60. https://doi.org/10.1002/ijc.10466
  7. Goode EL, Ulrich CM, Potter J D (2002). Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev, 11, 1513-30.
  8. He J, Gu DF, Wu XG, et al (2005). Major causes of death among men and women in China. N Engl J Med, 353, 1124-34. https://doi.org/10.1056/NEJMsa050467
  9. Hoeijmakers JH (2001). Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-74. https://doi.org/10.1038/35077232
  10. Hong SH, Choi JK, Ahn DH, et al (2009). Association of the XRCC1 gene polymorphisms in patients with stomach cancer. Genes Genomics, 31, 435-41. https://doi.org/10.1007/BF03191857
  11. Hung RJ, Hall J, Brennan P, Boffetta P (2005). Genetic polymorphisms in the base excision repair pathway and cancer risk: a huge review. Am J Epidemiol, 162, 925-42. https://doi.org/10.1093/aje/kwi318
  12. Hu Z, Ma H, Chen F, Wei Q, Shen H (2005). XRCC1 polymorphis, and cancer risk: a meta-analysis of 38 casecontrol studies. Cancer Epidemiol Biomarkers Prev, 14, 1810-8. https://doi.org/10.1158/1055-9965.EPI-04-0793
  13. Jiang J, Zhang X, Yang H, Wang W (2009). Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology. Methods Mol Biol, 471, 305-33. https://doi.org/10.1007/978-1-59745-416-2_16
  14. Justenhoven C, Hamann U, Pesch B, et al (2004). ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a german population. Cancer Epidemiol Biomarkers Prev, 13, 2059-64.
  15. Keith WC (2003). XRCC1 and DNA strand break repair. DNA Repair, 2, 955-69. https://doi.org/10.1016/S1568-7864(03)00118-6
  16. Lamerdin JE, Montgomery MA, Stilwagen SA, et al (1995). Genomic sequence comparison of the human and mouse XRCC1 DNA-repair gene regions. Genomics, 25, 547-54. https://doi.org/10.1016/0888-7543(95)80056-R
  17. Lee S-G, Kim B, Choi J, et al (2002). Genetic polymorphisms of Xrcc1 and risk of gastric cancer. Cancer Letters, 187, 53-60. https://doi.org/10.1016/S0304-3835(02)00381-6
  18. Li J Y, Ershow AG, Chen ZJ, et al (1989). A case-control study of cancer of the esophagus and gastric cardia in Linxian. Int J Cancer, 43, 755-61. https://doi.org/10.1002/ijc.2910430502
  19. Lindahl T, Wood RD (1999). Quality control by DNA repair. Science, 286, 1897-905. https://doi.org/10.1126/science.286.5446.1897
  20. Li QW, Lu CR, Ye M, Xiao WH, Liang J (2012). Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Asian Pacific J Cancer Prev, 13, 191-4. https://doi.org/10.7314/APJCP.2012.13.1.191
  21. Liu A, Li K, Yang M, Xia L, Xu J (2009). Correlation of polymorphism of DNA repair Gene XRCC1 with susceptibility to gastric cancer in Shangdong Province [Chinese]. Zhonghua zhong liu fang zhi, 16, 489-93.
  22. Li WQ, Zhang L, Ma JL, et al (2009). Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population. Carcinogenesis, 30, 500-5. https://doi.org/10.1093/carcin/bgp018
  23. Lockett KL, Hall MC, Xu JF, et al (2004). The ADPRT V762a genetic variant contributes to prostate cancer susceptibility and deficient enzyme function. Cancer Research, 64, 6344-8. https://doi.org/10.1158/0008-5472.CAN-04-0338
  24. Loh M, Koh KX, Yeo BH, et al (2009). Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. Eur J Cancer, 45, 2562-8. https://doi.org/10.1016/j.ejca.2009.03.017
  25. Masson M, Niedergang C, Schreiber V, et al (1998). XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol, 18, 3563-71. https://doi.org/10.1128/MCB.18.6.3563
  26. Miao X, Zhang X, Zhang L, et al (2006). Adenosine diphosphate ribosyl transferase and X-Ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. Gastroenterology, 131, 420-7. https://doi.org/10.1053/j.gastro.2006.05.050
  27. Munoz N, Plummer M, Vivas J, et al (2001). A case-control study of gastric cancer in Venezuela. Int J Cancer, 93, 417-23. https://doi.org/10.1002/ijc.1333
  28. Palli D, Polidoro S, D'Errico M, et al (2010). Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer. Mutagenesis, 25, 569-75. https://doi.org/10.1093/mutage/geq042
  29. Qu T, Morimoto K (2005). X-ray repair cross-complementing group 1 polymorphisms and cancer risks in Asian populations: a mini review. Cancer Detect Prev, 29, 215-20. https://doi.org/10.1016/j.cdp.2005.04.002
  30. Ratnasinghe LD, Abnet C, Qiao YL, et al (2004). Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer. Cancer Lett, 216, 157-64. https://doi.org/10.1016/j.canlet.2004.03.012
  31. Safaee A, Moghimi-Dehkordi B, Fatemi SR, Maserat E, Zali MR (2011). Family history of cancer and risk of gastric cancer in Iran. Asian Pacific J Cancer Prev, 12, 3117-20.
  32. Schottenfeld D, Fraumeni JF (2006). Cancer epidemiology and prevention. D M Parkin and I. Bray F International patterns of cancer incidence and mortality, Version 3. Oxford University Press. New York, 101-38.
  33. Shen HB, Xu YC, Qian Y, et al (2000). Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. Int J Cancer, 88, 601-6. https://doi.org/10.1002/1097-0215(20001115)88:4<601::AID-IJC13>3.0.CO;2-C
  34. Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
  35. Shen X, Zhang J, Yan Y, et al (2009). Analysis and estimates of the attributable risk for environmental and genetic risk factors in gastric cancer in a Chinese population. J Toxicol Environ Health A, 72, 759-66. https://doi.org/10.1080/15287390902841599
  36. Tran GD, Sun D, Abnet C, et al (2005). Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer, 113, 456-63. https://doi.org/10.1002/ijc.20616
  37. Vodicka P, Stetina R, Polakova V, et al (2007). Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis, 28, 657-64.
  38. Wang YG, Zheng TY (2012). XRCC1-77T>C polymorphism and cancer risk: a meta-analysis. Asian Pacific J Cancer Prev, 13, 111-5. https://doi.org/10.7314/APJCP.2012.13.1.111
  39. Wu MS, Chen CJ, Lin JT (2005). Host-environment interactions: their impact on progression from gastric inflammation to carcinogenesis and on development of new approaches to prevent and treat gastric cancer. Cancer Epidemiol Biomarkers Prev, 14, 1878-82. https://doi.org/10.1158/1055-9965.EPI-04-0792
  40. Xue H, Ni P, Lin B, Xu H, Huang G (2011). X-ray repair crosscomplementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: a huge review and meta-analysis. Am J Epidemiol, 173, 363-75. https://doi.org/10.1093/aje/kwq378
  41. Yang L (2006). Incidence and mortality of gastric cancer in China. World J Gastroenterol, 12, 17-20. https://doi.org/10.3748/wjg.v12.i1.17
  42. Yan L, Yanan D, Donglan S, et al (2009). Polymorphisms of XRCC1 gene and risk of gastric cardiac adenocarcinoma. Dis Esophagus, 22, 396-401. https://doi.org/10.1111/j.1442-2050.2008.00912.x
  43. Yuan T, Deng S, Chen M, et al (2010). Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 35, 170-4.
  44. Zhang Q, Li Y, Li X, et al (2009). PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population. Mol Biol Rep, 36, 1461-7. https://doi.org/10.1007/s11033-008-9336-y
  45. Zhang X, Miao X, Liang G, et al (2005). Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res, 65, 722-6.
  46. Zhang Z, Miao X-P, Tan W, et al (2006). Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer. Chinese J Cancer, 25, 7-10 [Chinese].
  47. Zhao Y, Deng X, Wang Z, Wang Q, Liu Y (2012). Genetic polymorphisms of DNA repair Genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. Asian Pacific J Cancer Prev, 13, 665-9. https://doi.org/10.7314/APJCP.2012.13.2.665

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