Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Accuracy of Frozen Sections for Intraoperative Diagnosis of Complex Atypical Endometrial Hyperplasia

  • Turan, Taner (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Karadag, Burak (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Karabuk, Emine (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Tulunay, Gokhan (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Ozgul, Nejat (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Gultekin, Murat (Cancer Control Department, Turkish Ministry of Health) ;
  • Boran, Nurettin (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Isikdogan, Zuhal (Pathology Division Etlik Zubeyde Hanim Women's Health Research and Teaching Hospital) ;
  • Kose, Mehmet Faruk (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital)
  • Published : 2012.05.30
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Abstract

Objective: The purpose of this study was to correlate the histological diagnosis made during intraoperative frozen section (FS) examination of hysterectomy samples with complex atypical endometrial hyperplasia (CAEH) diagnosed with definitive paraffin block histology. Methods: FS pathology results of 125 patients with a preoperative biopsy showing CAEH were compared retrospectively with paraffin block pathology findings. Results: Paraffin block results were consistent with FS in 78 of 125 patients (62.4%). The FS sensitivity and specificity of detecting cancer were 81.1% and 97.9%, with negative and positive predictive values of 76.7%, and 98.4%, respectively. Paraffin block results were reported as endometrial cancer in 77 of 125 (61.6%) patients. Final pathology was endometrial cancer in 45.3% patients diagnosed at our center and 76.9% for patients who had their diagnosis at other clinics (p=0.018). Paraffin block results were consistent with FS in 62.4% of all cases Consistence was 98.4% in patients who had endometrial cancer in FS. Conclusion: FS does not exclude the possibility of endometrial cancer in patients with the preoperative diagnosis of CAEH. In addition, sufficient endometrial sampling is important for an accurate diagnosis.

Keywords

References

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