Asian Pacific Journal of Cancer Prevention

  • 제13권5호
  • /
  • Pages.1877-1880
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid

  • Hong, Ri (Department of Breast, the First School of Clinical Medicine, Zhejiang Chinese Medical University) ;
  • Shen, Min-He (Department of Oncology, the First School of Clinical Medicine, Zhejiang Chinese Medical University) ;
  • Xie, Xiao-Hong (Department of Breast, the First School of Clinical Medicine, Zhejiang Chinese Medical University) ;
  • Ruan, Shan-Ming (Department of Oncology, the First School of Clinical Medicine, Zhejiang Chinese Medical University)
  • 발행 : 2012.05.30
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초록

Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.

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참고문헌

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  5. Hypermethylation of TET1 Promoter Is a New Diagnosic Marker for Breast Cancer Metastasis vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.1197
  6. Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members vol.29, pp.10, 2015, https://doi.org/10.1002/ptr.5402
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  8. Antitumor activity of the pachymic acid in nasopharyngeal carcinoma cells vol.41, pp.3, 2017, https://doi.org/10.1080/01913123.2017.1296522
  9. The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis pp.1861-0293, 2018, https://doi.org/10.1007/s11418-017-1117-2
  10. Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach vol.2018, pp.1741-4288, 2018, https://doi.org/10.1155/2018/5059743
  11. Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos vol.23, pp.8, 2018, https://doi.org/10.3390/molecules23081839