Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Effect of Electron Beam Irradiation on the Anti-allergy Activity of β-Glucan

전자선 조사가 베타글루칸의 항알레르기 활성에 미치는 영향

  • Park, Jong-Heum (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Sung, Nak-Yun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Byun, Eui-Beak (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Song, Du-Sup (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kim, Jaekyung (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Song, Beom-Seok (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Sang-Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Shin, Mi-Hae (Department of Food Technology and Services, College of Health Industry, Eulji University) ;
  • Lee, Ju-Woon (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kim, Jae-Hun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Yoo, Young-Choon (Department of Microbiology, College of Medicine, Konyang University)
  • 박종흠 (한국원자력연구원 정읍방사선과학연구소) ;
  • 성낙윤 (한국원자력연구원 정읍방사선과학연구소) ;
  • 변의백 (한국원자력연구원 정읍방사선과학연구소) ;
  • 송두섭 (한국원자력연구원 정읍방사선과학연구소) ;
  • 김재경 (한국원자력연구원 정읍방사선과학연구소) ;
  • 송범석 (한국원자력연구원 정읍방사선과학연구소) ;
  • 박상현 (한국원자력연구원 정읍방사선과학연구소) ;
  • 신미혜 (을지대학교 보건산업대학 식품산업외식학과) ;
  • 이주운 (한국원자력연구원 정읍방사선과학연구소) ;
  • 김재훈 (한국원자력연구원 정읍방사선과학연구소) ;
  • 유영춘 (건양대학교 의과대학 미생물학교실)
  • Received : 2012.07.05
  • Accepted : 2012.08.03
  • Published : 2012.09.30

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Abstract

This study evaluated the change in anti-allergy activity of ${\beta}-glucan$ by electron beam irradiation. ${\beta}-Glucan$ was irradiated at dose of 50 kGy and then orally pre-treated with electron beam irradiated and non irradiated ${\beta}-Glucan$ for 7 days. After pre-treatment, allergy was induced by injection of ovalbumin (OVA). Serum total immunoglobulin E (IgE) and OVA-specific IgE levels in the allergic mice was significantly increased but the mice pre-treated 50 kGy electron beam irradiated ${\beta}-glucan$ was significantly decreased the levels of total IgE and OVA-specific IgE, respectively. Moreover, cytokine production (interleukin-4) was also decreased in the 50 kGy electron beam irradiated ${\beta}-Glucan$ pre-treated mice. These results indicate that pre-treatment of 50 kGy electron beam irradiated ${\beta}-glucan$ may elevate the anti-allergy activity. Therefore, electron beam-irradiated ${\beta}-glucan$ could be used for nutraceutical foods in food industry.

Keywords

Acknowledgement

Supported by : 한국연구재단