한국축산식품학회지 (Food Science of Animal Resources)

  • 제32권4호
  • /
  • Pages.389-395
  • /
  • 2012
  • /
  • 2636-0772(pISSN)
  • /
  • 2636-0780(eISSN)
한국축산식품학회 (Korean Society for Food Science of Animal Resources)
권호 표지
DOI QR코드

DOI QR Code

Foods Derived from Cloned Animals and Management Policies in Worldwide

  • Lee, Soo-Jin (College of Veterinary Medicine and Department of Veterinary Public Health, Konkuk University) ;
  • Jang, Yang-Ho (College of Veterinary Medicine and Department of Veterinary Public Health, Konkuk University) ;
  • Kim, Hyo-Bi (College of Veterinary Medicine and Department of Veterinary Public Health, Konkuk University) ;
  • Lee, Myoung-Heon (Animal Plant and Fisheries Quarantine and Inspection Agency) ;
  • So, Byung-Jae (Animal Plant and Fisheries Quarantine and Inspection Agency) ;
  • Yang, Byoung-Chul (Animal Biotechnology Division, National Institute of Animal Science, RDA) ;
  • Kang, Jong-Koo (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Choe, Nong-Hoon (College of Veterinary Medicine and Department of Veterinary Public Health, Konkuk University)
  • 투고 : 2011.12.01
  • 심사 : 2012.06.12
  • 발행 : 2012.08.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Cloned animals are a result of asexual reproduction of animals using somatic cell nuclear transfer. Ever since the first report of a cloned sheep 'Dolly' produced by SCNT, increasing numbers of livestock, such as bovine and swine clones, have been generated worldwide. Foods derived from cloned animals have not been produced yet. However, the food safety of cloned animals has provoked controversy. The EU Food Safety Authority and U.S. Food and Drug Administration announced that milk and meat from cloned and non-cloned animals have no difference regarding food safety. However, food derived from cloned animals is considered unsuitable for eating vaguely. Moreover, there were scant information about cloned animals in Korea. Therefore, we surveyed the number of cloned animals worldwide including Korea and summarized the reports for cloned animals and discussed predictable problems.

키워드

참고문헌

  1. Caballero, B. (2003) Encyclopedia of Food Sciences and Nutrition. Editor. Elsevier Science Ltd., pp. 3957-3963.
  2. Chavatte-Palmer, P., Remy, D., Cordonnier, N., Richard, C., Issenman, H., Laigre, P., Heyman, Y., and Mialot, J. P. (2004) Health status of cloned cattle at different ages. Cloning Stem Cells 6, 94-100. https://doi.org/10.1089/1536230041372274
  3. Cibelli, J. B., Stice, S. L., Golueke, P. J., Kane, J. J., Jerry, J., Blackwell, C., Ponce de Leon, F. A., and Robl, J. M. (1998) Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 280, 1256-1258. https://doi.org/10.1126/science.280.5367.1256
  4. Chesne, P., Adenot, P. G., Viglietta, C., Baratte, M., Boulanger, L., and Renard, J. P. (2002) Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat. Biotechnol, 20, 366-369. https://doi.org/10.1038/nbt0402-366
  5. Codex (2009) Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA animals CAC/GL 68-2008. Available from:http://www.codexalimentarius.net/download/standards/10007/CXG_044e.pdf. Accessed May. 2009.
  6. Diles, J. J. B., Green, R. D., Shepherd, H. H.,Mathiews, G. L., Hughes, L. J., and Miller. M. F. (1996) Relationships between body measurements obtained on yearling Brangus bulls and measures of carcass merit obtained from their steer clonemates. PAS 12, 244-249.
  7. European Food Safety Authority (EFSA) (2009) Animal Health and Welfare and Environmental Impact of Animals1 derived from Cloning by Somatic Cell Nucleus Transfer (SCNT) and their Offspring and Products Obtained from those Animals, DRAFT Scientific Opinion of the Scientific Committee: Available from: http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1211902019540.htm. Accessed Oct. 2009.
  8. European commission (2008) Europeans' attitudes towards animal cloning : Analytical Report. Available from : http://ec.europa.eu/food/food/resources/docs/eurobarometer clomingen.pdf. Acessed Feb. 2009.
  9. Faber, D. C,, Ferre, L. B., Metzger, J., Robl, J. M., and Kasinathan, P. (2004) Agro-economic impact of cattle cloning. Cloning Stem Cells 6, 198-207. https://doi.org/10.1089/1536230041372463
  10. Food and Agriculture Organization (FAO) (2000) Safety aspects of genetically modified foods of plant origin. Report of a joint FAO/WHO expert consultation on foods derived from biotechnology. FAO/WHO, 2000. Available from:http://ftp.fao.org/es/esn/ffod/gmreport.pdf. Accessed Dec. 2008.
  11. Food and Agriculture Organization (FAO) (2002) Report of the third session of the codex ad hoc intergovernmental task force on foods derived from biotechnology (ALINORM 01/34) FAO/WHO, 2002. Available from:ftp://ftp.fao.org/codex/alinorm03/A103 34e.pdf. Accessed Dec. 2008.
  12. Food and Drug Administration (FDA) (2006) Guideline No. 179: Guidance for industry use of animal clones and clone progeny for human food and animal feed. Available from http://www.fda.gov/cvm/Guidance/Finalguideline179.htm. Accessed Feb. 2009.
  13. Food and Drug Administration (FDA) (2008a) Animal cloning risk assessment for clones and their progeny, Available from: http://www.fda.gov/cvm/cloningRA_RiskMngt.htm. Accessed Feb. 2009a.
  14. Food Safety Commission (2009) Risk assessment of food derived from cattle, porcine and their progeny by animal cloning. Novel food investment working group (Japanese).
  15. Food Standard Australia New Zealand (FSANZ) (2003) Review on the current status of the extent and use of cloning in animal production in Australia and New Zealand. Available from: http://www.foodstandards.gov.au/_srcfiles/Cloning_Review_Final_June%202003.pdf. Assessed Oct. 2009.
  16. Galli, C., Lagutina, I., Crotti, G., Colleoni, S., Turini, P., Ponderato, N., Duchi, R., and Lazzari, G. (2003) Pregnancy: a cloned horse born to its dam twin. Nature 424, 635.
  17. Health Canada (2003) Food Directorate Interim Policy on Foods from Cloned Animals. Available from: http://www.hcsc.gc.ca/fn-an/alt_formats/hpfb-dgpsa/pdf/legislation/pol-cloned_animal-clones_animaux-eng.pdf. Accessed Sep. 2009.
  18. Heyman, Y., Richard, C., Rodriguez-Martinez, H., Lazzari, G., Chavatte-Palmer, P., Vignon, X., and Galli, C. (2004) Zootechnical performance of cloned cattle and offspring: preliminary results. Cloning Stem Cells. 6, 111-120. https://doi.org/10.1089/1536230041372364
  19. Heyman, Y., Chavatte-Palmer, P., Berthelot, V., Fromentin, G., Hocquette, J. F., Martignat, L., and Renard, J. P. (2007) Assessing the quality of products from cloned cattle: an integrative approach. Theriogenology 67, 134-141. https://doi.org/10.1016/j.theriogenology.2006.09.020
  20. Hwang, S., Lee, N. J., Hwang, J. S., Yang, B. C., Im, G. S., Ko, Y. G., Park, E. W., Park, S. B., Kang, J. K., and Seong, H. H. (2010) Effects of cloned-cattle meat on reproductive physiology in rats. Animal 4, 218-223. https://doi.org/10.1017/S1751731109990966
  21. Jablonka, E. and Lamb, M. J. (2003) The changing concept of epigenetics. Ann. N Y Acad. Sci. 981, 82-96 (2003)
  22. Jensen, R. G., Couch, S. C., Bitman, J., Carlson, S. E., Hamosh, M., Newburg, D. S., and Robert, G. J. (1995) Handbook of Milk Composition. Editor. Academic Press, San Diego, p. 1574.
  23. Keefer, C. L., Baldassarre, H., Keyston, R., Wang, B., Bhatia, B., Bilodeau, A. S., Zhou, J. F., Leduc, M., Downey, B. R., Lazaris, A., and Karatzas, C. N. (2001) Generation of dwarf goat (Capra hircus) clones following nuclear transfer with transfected and nontransfected fetal fibroblasts and in vitromatured oocytes. Biol. Reprod. 64, 849-856. https://doi.org/10.1095/biolreprod64.3.849
  24. Kim, M. K., Jang, G., Oh, H. J., Yuda, F., Kim, H. J., Hwang, W. S., Hossein, M. S., Kim, J. J., Shin, N. S., Kang, S. K., and Lee, B. C. (2007) Endangered wolves cloned from adult somatic cells. Cloning Stem Cells 9, 130-137. https://doi.org/10.1089/clo.2006.0034
  25. Lee, B. C., Kim, M. K., Jang, G., Oh, H. J., Yuda, F., Kim, H. J., Hossein, M. S., Kim, J. J., Kang, S. K., Schatten, G., and Hwang, W. S. (2005) Dogs cloned from adult somatic cells. Nature 436, 641. https://doi.org/10.1038/436641a
  26. Lee, N. J., Yang, B. C., Hwang, J. S., Im, G. S., Ko, Y. G., Park, E. W., Seong, H. H., Park, S. B., Kang, J. K., and Hwang, S. S. (2010) Effects of cloned-cattle meat diet on reproductive parameters in pregnant rabbits. Food Chem. Toxicol. 48, 871-876. https://doi.org/10.1016/j.fct.2009.12.025
  27. Lee, N. J., Yang, B. C., Jung, Y. R., Lee, J. W., Im, G. S., Seong, H. H., Park, J. K., Kang, J. K., and Hwang, S. S. (2011) In vitro and in vivo genotoxic effects of somatic cell nuclear transfer cloned cattle meat. Food Chem. Toxicol. 49, 2273-2278. https://doi.org/10.1016/j.fct.2011.06.026
  28. Mir, B., Zaunbrecher, G., Archer, G. S., Friend, T. H., and Piedrahita, J. A. (2005) Progeny of somatic cell nuclear transfer (SCNT) pig clones are phenotypically similar to noncloned pigs. Cloning Stem Cells. 7, 119-125. https://doi.org/10.1089/clo.2005.7.119
  29. Norman, H. D. and Walsh, M. K. (2004) Performance of dairy cattle clones and evaluation of their milk composition. Cloning Stem Cells. 6, 157-164. https://doi.org/10.1089/1536230041372346
  30. Norman, H. D., Lawlor, T. J., Wright, J. R., and Powell, R. L. (2004) Performance of Holstein clones in the United States. J. Dairy Sci. 87, 729-738. https://doi.org/10.3168/jds.S0022-0302(04)73216-6
  31. Onishi, A., Iwamoto, M., Akita, T., Mikawa, S., Takeda, K., Awata, T., Hanada, H., and Perry, A. C. (2000) Pig cloning by microinjection of fetal fibroblast nuclei. Science 289, 1188-1190. https://doi.org/10.1126/science.289.5482.1188
  32. Palmquist, D. L., Beaulieu, A. D., and Barbano, D. M. (1993) Feed and animal factors influencing milk fat composition. J. Dairy Sci. 76, 1753-1771. https://doi.org/10.3168/jds.S0022-0302(93)77508-6
  33. Panarace, M., Aguero, J. I., Garrote, M., Jauregui, G., Segovia, A., Cane, L., Gutierrez, J., Marfil, M., Rigali, F., Pugliese, M., Young, S., Lagioia, J., Garnil, C., Forte Pontes, J. E., Ereno Junio, J. C., Mower, S., and Medina, M. (2007) How healthy are clones and their progeny: 5 years of field experience. Theriogenology. 67, 142-151. https://doi.org/10.1016/j.theriogenology.2006.09.036
  34. Polejaeva, I. A., Chen, S. H., Vaught, T. D., Page, R. L., Mullins, J., Ball, S., Dai, Y., Boone, J., Walker, S., Ayares, D. L., Colman, A., and Campbell, K. H. (2000) Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 407, 86-90. https://doi.org/10.1038/35024082
  35. Shibata, M., Otake, M., Tsuchiya, S., Chikyu, M., Horiuchi, A., and Kawarasaki, T. (2006) Reproductive and growth performance in Jin Hua pigs cloned from somatic cell nuclei and the meat quality of their offspring. J. Reprod. Dev. 52, 583-590. https://doi.org/10.1262/jrd.18004
  36. Shin, T., Kraemer, D., Pryor, J., Liu, L., Rugila, J., Howe, L., Buck, S., Murphy, K., Lyons, L. and Westhusin, M. (2002) A cat cloned by nuclear transplantation. Nature 415, 859. https://doi.org/10.1038/nature723
  37. Takahashi, S. and Ito, Y. (2004) Evaluation of meat products from cloned cattle: biological and biochemical properties. Cloning Stem Cells. 6, 165-171.
  38. Tian, X. C., Kubota, C., Sakashita, K., Izaike, Y., Okano, R., Tabara, N., Curchoe, C., Jacob, L., Zhang, Y., Smith, S., Bormann, C., Xu, J., Sato, M., Andrew, S., and Yang, X. (2005) Meat and milk compositions of bovine clones. Proc. Natl. Acad. Sci. USA 102, 6261-6266. https://doi.org/10.1073/pnas.0500140102
  39. Tome, D., Dubarry, M., and Fromentin, G. (2004) Nutritional value of milk and meat products derived from cloning. Cloning Stem Cells 6, 172-177. https://doi.org/10.1089/1536230041372445
  40. Walsh, M. K., Lucey, J. A., Govindasamy-Lucey, S., Pace, M. M., and Bishop, M. D. (2003) Comparison of milk produced by cows cloned by nuclear transfer with milk from noncloned cows. Cloning Stem Cells. 5, 213-219. https://doi.org/10.1089/153623003769645875
  41. Walker, S., Christenson, R., Ruiz, R., Reeves, D., Pratt, S., Arenivas, F., Williams, N., Bruner, B., and Polejaeva, I. (2007) Comparison of meat composition from offspring of cloned and conventionally produced boars. Theriogenology. 67, 178-184. https://doi.org/10.1016/j.theriogenology.2006.09.025
  42. Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J., and Campbell, K. H. (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810-813. https://doi.org/10.1038/385810a0
  43. Yamaguchi, M., Ito, Y., and Takahashi, S. (2007) Fourteenweek feeding test of meat and milk derived from cloned cattle in the rat. Theriogenology, 67, 152-165. https://doi.org/10.1016/j.theriogenology.2006.09.010
  44. Yamaguchi, M., Ito, Itoh M., Ito, Y., and Watanabe, S. (2008) A 12 month feeding study of reproduction/development in rats fed meat/milk powder supplemented diets derived from the progeny of cloned cattle produced by somatic cell nuclear transfer. J. Reprod. Dev. 54, 321-334. https://doi.org/10.1262/jrd.20060
  45. Yang, B. C., Lee, N. J., Im, G. S., Seoung, H. H., Park, J. K., Kang, J. K., and Hwang, S. S. (2011) A diet of somatic cell nuclear transfer cloned-cattle meat produced no toxic effects on behavioral or reproductive characteristics of F1 rats derived from dams fed on cloned-cattle meat. Birth Defects Res. Part B. 92, 224-230. https://doi.org/10.1002/bdrb.20309
  46. Yang, L., Chavatte-Palmer, P., Kubota, C., O'neill, M., Hoagland, T., Renard, J.P., Taneja, M., Yang, X., and Tian, X. C. (2005) Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones. Mol. Reprod. Dev. 71, 431-438. https://doi.org/10.1002/mrd.20311
  47. Yang, X., Tian, X. C., Kubota, C., Page, R., Xu, J., Cibelli, J., and Seidel, G., Jr. (2007) Risk assessment of meat and milk from cloned animals. Nat. Biotechnol. 25, 77-83. https://doi.org/10.1038/nbt1276