BMB Reports

생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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The role of protein arginine-methyltransferase 1 in gliomagenesis

  • Wang, Shan (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Tan, Xiaochao (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Yang, Bin (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Yin, Bin (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Yuan, Jiangang (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Qiang, Boqin (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Peng, Xiaozhong (The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College)
  • 투고 : 2012.01.25
  • 심사 : 2012.02.24
  • 발행 : 2012.08.31
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초록

Protein arginine methyltransferase 1 (PRMT1), a type-I arginine methyltransferase, has been implicated in diverse cellular events. We have focused on the role of PRMT1 in gliomagenesis. In this study, we showed that PRMT1 expression was up-regulated in glioma tissues and cell lines compared with normal brain tissues. The knock-down of PRMT1 resulted in an arrest in the G1-S phase of the cell cycle, proliferation inhibition and apoptosis induction in four glioma cell lines (T98G, U87MG, U251, and A172). Moreover, an in vivo study confirmed that the tumor growth in nude mouse xenografts was significantly decreased in the RNAi-PRMT1 group. Additionally, we found that the level of the asymmetric dimethylated modification of H4R3, a substrate of PRMT1, was higher in glioma cells than in normal brain tissues and decreased after PRMT1 knock-down. Our data suggest a potential role for PRMT1 as a novel biomarker of and therapeutic target in gliomas.

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참고문헌

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피인용 문헌

  1. Selective Inhibitors of Protein Methyltransferases vol.58, pp.4, 2015, https://doi.org/10.1021/jm501234a
  2. PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology vol.33, pp.3, 2015, https://doi.org/10.1002/stem.1894
  3. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients vol.19, pp.3, 2016, https://doi.org/10.1007/s10120-015-0551-7
  4. Discovery and structure–activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors vol.25, pp.22, 2015, https://doi.org/10.1016/j.bmcl.2015.06.095
  5. Deregulation of histone-modifying enzymes and chromatin structure modifiers contributes to glioma development vol.11, pp.18, 2015, https://doi.org/10.2217/fon.15.171
  6. Small-molecular modulators of cancer-associated epigenetic mechanisms vol.9, pp.5, 2013, https://doi.org/10.1039/c3mb25410k
  7. Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors 2017, https://doi.org/10.1111/cbdd.13047
  8. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases vol.11, pp.3, 2016, https://doi.org/10.1021/acschembio.5b00839
  9. Effects of telomerase inhibitor on epigenetic chromatin modification enzymes in malignancies vol.119, pp.12, 2018, https://doi.org/10.1002/jcb.27301
  10. PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma vol.9, pp.1, 2018, https://doi.org/10.1038/s41467-018-06968-7
  11. Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells vol.9, pp.1, 2019, https://doi.org/10.1038/s41598-018-38394-6