Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Regulation of Endoplasmic Reticulum Stress Response by the Immobilization Stress

부동스트레스에 의한 소포체스트레스반응 조절

  • Kwon, Ki-Sang (Departments of Anatomy, School of Medicine, Chungnam National University,) ;
  • Kwon, Young-Sook (Department of Emergency Medicine, Chungnam National University Hospital) ;
  • Kim, Seung-Whan (Department of Nursing, Joongbu University) ;
  • Kim, Dong-Woon (Departments of Anatomy, School of Medicine, Chungnam National University,) ;
  • Kwon, O-Yu (Departments of Anatomy, School of Medicine, Chungnam National University,)
  • Received : 2012.07.03
  • Accepted : 2012.08.08
  • Published : 2012.08.30
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Abstract

Many kind of cell stresses induce gene expression of unfolded protein response (UPR)-associated factors. This study demonstrated that up- and down-regulation of gene expression of endoplasmic reticulum (ER) stress chaperones and ER stress sensors was induced by immobilization stress in the rat organs (adrenal gland, liver, lung, muscle). However, no statistically significant regulation was detected in the others (heart, spleen, thymus, kidney, testis). The results are the first to show that immobilization stress induces UPR associated gene expression, will help to explain immobilization stress-associated ER stress.

많은 종류의 세포스트레스는 unfolded protein response (UPR)관련인자의 유전자발현을 조절한다. 본 연구결과 부동스트레스(immobilization stress)는 세포의 소포체스트레스(ER stress)와 관련된 유전자발현의 변화를 유도한다; Heart, spleen, thymus, kidney, testis에서는 유전자발현 변화가 없었지만 adrenal gland, liver, lung에서는 유의할만한 상승변화가 있었다. 그러나 muscle에서는 다른 것들과 대조적으로 발현이 감소되었다. 이 결과는 부동스트레스도 다른 종류의 세포스트레스와 같이 세포수준에서 UPR을 조절할 수 있다는 최초의 보고이다.

Keywords

References

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