YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Change of Plasma Neurotransmitters Concentration after Aromatherapy in Dementia Patients

라벤더향 흡입 후 치매환자의 혈장 중 신경전달물질의 농도변화

  • 이경복 (숙명여자대학교 약학대학) ;
  • 강영숙 (숙명여자대학교 약학대학)
  • Received : 2012.01.10
  • Accepted : 2012.02.23
  • Published : 2012.04.30
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Abstract

The objective of this study is to examine how different concentration of neurotransmitters in plasma between patients with dementia and normal people regarding the inhalation of lavender oil. This study subjects were 9 elderly patients with dementia who live in nursing home and 9 normal women. Before and after inhalation, they were collected blood sample. Norepinephrine (NE), serotonin (5-HT), dopamine (DA), and r-aminobutyric acid (GABA) concentration analysis were performed. Before inhalation, dementia patients were significantly different with the normal group in GABA and DA, NE. Following inhalation in experimental group, dementia patients and normal group were only significantly increased in 5-HT. But it did not significantly change in the other neurotransmitters. After inhalation, dementia patients were significantly different with the normal group in GABA and 5-HT. This result suggests that the increase of 5-HT release by the inhalation of lavender oil related to reduce the behavioral and psychological symptoms of dementia.

Keywords

References

  1. Yamada, K. : Effects of inhaling of lavander oil or linaool vapor on ether induced plasmas ACTH, catecholamine and gonadotropine levels in experimental menopausal female rat. Aroma. Res. 5, 65 (2004).
  2. Perry, N. and Perry, E. : Aromatherapy in the management of psychiatric disorders; clinical and neuron. CNS Drugs. 20, 257 (2006).
  3. Neale, L., Moss, L. and Moss, M. : Lavender aroma moderates endocrine response to an acute psychological stress. Intern. J. Clin. Aromather. 5, 3 (2008).
  4. Finkel, S. I., Costa, J., Cohen, G., Miller, S. and Sartorius, N. : Behavioral and psychological signs and symptoms of dementia; a consensus statement on current knowledge and implications for research and treatment. Intern. J. Psychogeriatrics. 8, 497 (1996).
  5. Buckle, J. : Use of aromatherapy as a complementary treatment for chronic pain. Alter. Ther. 5, 42 (1999).
  6. 이선영 : 라벤더 향요법 손마사지가 치매노인의 인지기능, 정서 및 공격행동에 미치는 효과. 대한간호학회지 35, 303 (2005).
  7. Herrmann, N., Lanctot, K. L. and Mazzotta, P. : The role of serotonin the behavioral and psychological symptoms of dementia. J. Neuropsychiatry Clin. Neurosci. 13, 5 (2001).
  8. Sebastiaan, E., Ellen, V., Nathalie, L. B., Michael, V. B., Peter, M., Nore, S., Guy, N., Barbara, A. and Pickut, P. D. D. : The dopamiergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia. Neurochem. Intern. 52, 1052 (2008).
  9. Nguyen, Q. A. and Paton, C. : The use of aromatherapy to treat behavioural problems in dementia. Intern. J. Geriatric Psychiatry 23, 337 (2008).
  10. 이지원, 신유선, 정유선: 아로마요법이 간호대학생의 자율신경계 활성에 미치는 효과. 한국모자보건학회지 9, 237 (2005).
  11. Lin, W., Chan, W. C., Ng, B. F. and Larn, L. C. : Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Intern. J. Geriatric Psychiatry 22, 405 (2007).
  12. 신유선, 정영숙, 정유진 : 아로마요법이 뇌졸증 환자의 자율신경계와 스트레스에 대한 신체 저항도에 미치는 효과. 대한기초간호학회지 6, 5 (2004).
  13. 최승완 : 아로마요법이 치매행동심리증상에 미치는 효과. 한국노년학 28, 1069 (2008).
  14. Cook, N. : Aromatherapy: Reviewing evidence for its mechanism of action and central nervous system effect. British J. Neurosci. Nursing. 4, 596 (2008).
  15. Shawa, D., Annettb, J. M., Dohertyc, B. and Lesliea, J. C. : Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. Phytomed. 14, 613 (2007).
  16. Niijima, A. : Effect of olfactory stimulation on autonomic nerve activity and metabolism. Autonomic Nervous System-Tokyo 45, 178 (2008).
  17. Maria, L. : Lavender, 1th ed., Taylor & Francis Inc. London and New York, p.268 (2002).
  18. 김재철, 천성희, 변상현 : 아로마요법이 신생아의 스트레스 호르몬에 미치는 영향. 충남의대잡지 30, 5 (2003).
  19. John, T., David, A. and Isaac, S. : HPA axis function in depression and dementia: a review. Intern. J. Geriatric Psychiatry 8, 887 (1993).
  20. Lanctot, K. L., Herrmann, N., Rothenburg, L. and Eryavec, G. : Behavioral correlates of GABAergic disruption in alzheimer's disease. Intern. Psychogeriatr. 19, 151 (2006).
  21. Herrmann, N., Lanctot, K. L. and Khan, L, R. : The role of NE in the behavioral and psychological symptoms of dementia. J. Neuropsychiatry Clin. Neurosci. 16, 261 (2004).
  22. Ziegler, M. G., Lake, C. R., Wood, T. H., Brooks, B. R. and Ebert, M. H. : Relationship between NE in blood and cerebrospinal fluid for the presence of a blood-cerebrospinal fluid barrier for NE. J. Neurochem. 28, 677 (1977).
  23. Nicolas, D., Vlachakis, C. L., Natalie, A. and Robert, F. M. : Catecholamine and their major metabolites in plasma and cerebrospinal fluid of man. Brain Res. 229, 67 (1981).
  24. Raskind, M. A, Peskind, E. R., Halter, J. B. and Jimerson, D. C. : Norepinaphrine and MHPG levels in CSF and plasma in Alzheimer's disease. Arch. Gen. Psychiatry 41, 343 (1984).
  25. Rachael, E. B. S., Elaine, R., Peskind, L. D., Kayla, I. B., Richard, C. V. and Murray, A. R. : Effect of alzhimer's disease severity on cerebrospinal fluid NE concentration. Am. J. Psychiatry 154, 25 (1997).
  26. Ebbe, E., Claus, H., Niels, J. C. and Klaus, O. : Plasma free and sulfoconjugated dopaminee in man: relationship to sympathetic activity, adrenal function and meals. Dan. Med. Bull. 35, 291 (1977).
  27. Khyaudeen, S. F. and Bakar, M. A. : Aromatherapy : It's effect on brain signal, math computation. Blood Pressure, Proceedings. 15, 44 (2007).
  28. Cavanagh, H. M. A. and Wikinson, J. M. : biological activities of lavender essential oil. Phytother Res. 16, 301 (2002).
  29. Ortiz, J., Artigas, F. and Gelpi, E. : Serotoninergic status in human blood. Life Sci. 43, 983 (1988).
  30. Sarrias, M. J., Artigas, F., Martinez, E., Gelpi, E., Alvarez, E., Udina, C. and Casas, M. : Decreased plasma serotonin in melancholic patients: A study with clomipramine. Biol. Psychiatry 22, 1429 (1987).