YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Effect of Natural Mate Tea Extract on the Body Weight and Biochemical Biomarker in High Fat Diet-Obese(ob/ob) Mice

천연마테차 물추출물의 고지방식이 비만쥐의 체중과 생화학적 변화에 미치는 영향

  • 김상태 (이화여자대학교 생명약학부) ;
  • 황초원 (이화여자대학교 생명약학부) ;
  • 김영균 (국민대학교 임산생명공학과 천연물연구실)
  • Received : 2011.05.24
  • Accepted : 2011.12.18
  • Published : 2012.02.29
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Abstract

In this study, we investigated the anti-obese activity of sevennight extract in high fat diet-ob/ob C57BL/6J mice by oral administered for 1 weeks. Mate water extract (MATEWi) was found to lower whole body and epididymal adipose tissue weights and lowered plasma levels of triglyceride (TG) and total cholesterol (TC), HDL and LDL, compared to those in high fat fed ob/ob group. These results suggest that Mate extract ameliorates obesity through activation of lipogenic enzymes and FA oxidation resulting from phosphorylation of AKT and GSK-$3{\beta}$, and could be developed as a potential therapeutic agent for obese mices.

Keywords

References

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