Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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A Case of Intracranial Involvement in Plasma Cell Myeloma

두개 내를 침범한 형질세포골수종 1예

  • Lee, Su-Hyun (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Chung, Yoon-Yung (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Lim, Ye-Jee (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Ko, Sun-Young (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Choi, Yoo-A (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Kim, Young-Woon (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Lee, Sung-Eun (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Park, Chong-Won (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea, College of Medicine)
  • 이수현 (가톨릭대학교 의과대학 내과학교실) ;
  • 정윤영 (가톨릭대학교 의과대학 내과학교실) ;
  • 임예지 (가톨릭대학교 의과대학 내과학교실) ;
  • 고선영 (가톨릭대학교 의과대학 내과학교실) ;
  • 최유아 (가톨릭대학교 의과대학 내과학교실) ;
  • 김영운 (가톨릭대학교 의과대학 내과학교실) ;
  • 이성은 (가톨릭대학교 의과대학 내과학교실) ;
  • 박종원 (가톨릭대학교 의과대학 내과학교실)
  • Published : 2012.06.30
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Abstract

Plasma cell myelomas generally manifest as bone or soft-tissue tumors with variable mass effects, pain, and infiltrative behavior. Extramedullary involvement occurs most commonly in the spleen, liver, lymph nodes, and kidneys, but intracranial involvement in plasma cell myeloma is a rare extramedullary manifestation. These authors recently encountered a case of intracranial involvement of plasma cell myeloma. A 69-year-old man was hospitalized for headache and mental changes. Brain CT showed subdural hemorrhage caused by plasma cell myeloma. Plasma cell myeloma with intracranial involvement has poor prognosis, and the patient in this case died from acute complications, such as subdural hemorrhage. Based on this case report, it is suggested that more effective treatment regimens of plasma cell myeloma with intracranial involvement be developed. Moreover, a screening method and decision on the appropriate time for intracranial involvement are needed for plasma cell myeloma patients.

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