Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

Experimental Study of Osseointegration and Stability of Intentionally Exposed Hydroxyapatite Coating Implants

의도적으로 연조직에 노출시킨 수산화인회석 코팅 임플란트의 골유착과 안정성에 대한 실험적 연구

  • Jeong, Kyung-In (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Su-Gwan (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Moon, Seong-Yong (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Oh, Ji-Su (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Jo, Ji-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Lim, Hyoung-Sup (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Jeong-Sun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Lim, Sung-Chul (Department of Pathology, School of Medicine, Chosun University) ;
  • Jeong, Mi-Ae (Department of Dental Hygiene, Kangwon National University)
  • 정경인 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김수관 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 문성용 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 오지수 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 조지호 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 임형섭 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김정선 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 임성철 (조선대학교 의학전문대학원 병리학교실) ;
  • 정미애 (강원대학교 치위생과)
  • Received : 2011.10.21
  • Accepted : 2011.11.22
  • Published : 2012.01.30
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: The purpose of this study is to evaluate the effect of exposure of hydroxyapatite coating on the amount of bone formation and stability in the dogs. Methods: In this study, hydroxyapatite coated implants (HAPTITE) was placed over the femur bone surface of four dogs about 1 mm. The experimental group was divided into 4 weeks group of 8 implants and 8 weeks group of 8 implants, and then they were sacrificed. The stability of implants was evaluated twice with Osstell$^{TM}$ mentor (Osstell AB, Goteborg, Sweden) at right after placement and sacrifice. The amount of bone formation was evaluated through histomorphometric examination. Results: The stability of implants was in normal range, and tended to increase as time goes by. Mean percentages of new bone formation rates were $90.5{\pm}6.6$ at uppermost 1 mm bone level adjacent to soft tissues (level 1) and $92.9{\pm}4.1$ at next 1 mm bone level (level 2) in 4 weeks group, $90.1{\pm}11.5$ at level 1 and $95.9{\pm}2.3$ at level 2 in 8 weeks group. Mean percentages of bone-implant contact rates were $85.1{\pm}10.8$ at level 1 and $88.1{\pm}13.8$ at level 2 in 4 weeks group, $88.5{\pm}14.4$ at level 1 and $95.3{\pm}3.1$ at level 2 in 8 weeks group. There was no statistically significant difference of new bone formation rate and bone-implant contact rate between uppermost 1 mm bone level adjacent to soft tissues and next 1 mm bone level. However, there was no significant difference in bone formation between 4 and 8 weeks groups. Conclusion: These results suggested that exposed hydroxyapatite coated implants to soft tissue showed favorable bone formation and implant stability.

Keywords

References

  1. Albrektsson T, Zarb G, Worthington P, Eriksson AR. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants 1986;1:11-25.
  2. Soballe K, Hansen ES, Brockstedt-Rasmussen H, Pedersen CM, Bunger C. Hydroxyapatite coating enhances fixation of porous coated implants. A comparison in dogs between press fit and noninterference fit. Acta Orthop Scand 1990;61: 299-306. https://doi.org/10.3109/17453679008993521
  3. Cook SD, Kay JF, Thomas KA, Jarcho M. Interface mechanics and histology of titanium and hydroxylapatite-coated titanium for dental implant applications. Int J Oral Maxillofac Implants 1987;2:15-22.
  4. Wheeler SL. Eight-year clinical retrospective study of titanium plasma-sprayed and hydroxyapatite-coated cylinder implants. Int J Oral Maxillofac Implants 1996;11:340-50.
  5. Whitehead RY, Lucas LC, Lacefield WR. The effect of dissolution on plasma sprayed hydroxylapatite coatings on titanium. Clin Mater 1993;12:31-9. https://doi.org/10.1016/0267-6605(93)90025-3
  6. Trisi P, Keith DJ, Rocco S. Human histologic and histomorphometric analyses of hydroxyapatite-coated implants after 10 years of function: a case report. Int J Oral Maxillofac Implants 2005;20:124-30.
  7. Hanks CT, Sun ZL, Fang DN, et al. Cloned 3T6 cell line from CD-1 mouse fetal molar dental papillae. Connect Tissue Res 1998;37:233-49. https://doi.org/10.3109/03008209809002442
  8. Hjorting-Hansen E, Worsaae N, Lemons JE. Histologic response after implantation of porous hydroxylapatite ceramic in humans. Int J Oral Maxillofac Implants 1990;5:255-63.
  9. Cook SD, Kay JF, Thomas KA, Jarcho M. Interface mechanics and histology of titanium and hydroxylapatite-coated titanium for dental implant applications. Int J Oral Maxillofac Implants 1987;2:15-22.
  10. Block MS, Kent JN, Kay JF. Evaluation of hydroxylapatite-coated titanium dental implants in dogs. J Oral Maxillofac Surg 1987;45:601-7. https://doi.org/10.1016/0278-2391(87)90270-9
  11. Misch CM. Hydroxylapatite-coated implants. Design considerations and clinical parameters. N Y State Dent J 1993;59: 36-41.
  12. Lee JH, Kim SG, Lim SC. Histomorphometric study of bone reactions with different hydroxyapatite coating thickness on dental implants in dogs. Thin Solid Film 2011;519:4618-22. https://doi.org/10.1016/j.tsf.2011.01.004
  13. Lee JJ, Rouhfar L, Beirne OR. Survival of hydroxyapatite-coated implants: a meta-analytic review. J Oral Maxillofac Surg 2000;58:1372-9. https://doi.org/10.1053/joms.2000.18269
  14. Heimann RB. Thermal spraying of biomaterials. Surf Coat Technol 2006;201:2012-9. https://doi.org/10.1016/j.surfcoat.2006.04.052
  15. Sun L, Berndt CC, Gross KA, Kucuk A. Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: a review. J Biomed Mater Res 2001;58:570-92. https://doi.org/10.1002/jbm.1056
  16. Kim TY, Ha JY, Kwon TY, Kim KH. Surface characterization of plasma sprayed Ti-6Al-4V alloy. Biomater Res 2008;12:114.
  17. Yoon HG, Heo SJ, Koak JY, Kim SK, Lee SY. Effect of bone quality and implant surgical technique on implant stability quotient (ISQ) value. J Adv Prosthodont 2011;3:10-5. https://doi.org/10.4047/jap.2011.3.1.10
  18. Oh JS, Kim SG, Lim SC, Ong JL. A comparative study of two noninvasive techniques to evaluate implant stability: Periotest and Osstell Mentor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:513-8. https://doi.org/10.1016/j.tripleo.2008.08.026
  19. Al-Nawas B, Wagner W, Grotz KA. Insertion torque and resonance frequency analysis of dental implant systems in an animal model with loaded implants. Int J Oral Maxillofac Implants 2006;21:726-32.
  20. Lee KW, Bae CM, Jung JY, et al. Surface characteristics and biological studies of hydroxyapatite coating by a new method. J Biomed Mater Res B Appl Biomater 2011;98B:395-407. https://doi.org/10.1002/jbm.b.31864
  21. Lucchini JP, Aurelle JL, Therin M, Donath K, Becker W. A pilot study comparing screw-shaped implants. Surface analysis and histologic evaluation of bone healing. Clin Oral Implants Res 1996;7:397-404. https://doi.org/10.1034/j.1600-0501.1996.070414.x
  22. Boyan BD, Schwartz Z, Lohmann CH, et al. Pretreatment of bone with osteoclasts affects phenotypic expression of osteoblast-like cells. J Orthop Res 2003;21:638-47. https://doi.org/10.1016/S0736-0266(02)00261-9