Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

The Relationship between Serum Ferritin Concentrations, Smoking and Lung Function in Korean

한국인에서 혈청 페리틴 농도와 흡연 및 폐기능과의 관계

  • Kim, Seo-Yun (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Su-Hwan (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, In-Seon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Sae-Byol (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Moon, Chan-Soo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Jung, Sung-Mo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Se-Kyu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Young-Sam (Department of Internal Medicine, Yonsei University College of Medicine)
  • 김서윤 (연세대학교 의과대학 내과학교실) ;
  • 이수환 (연세대학교 의과대학 내과학교실) ;
  • 이인선 (연세대학교 의과대학 내과학교실) ;
  • 김샛별 (연세대학교 의과대학 내과학교실) ;
  • 문찬수 (연세대학교 의과대학 내과학교실) ;
  • 정성모 (연세대학교 의과대학 내과학교실) ;
  • 김세규 (연세대학교 의과대학 내과학교실) ;
  • 김영삼 (연세대학교 의과대학 내과학교실)
  • Received : 2011.11.03
  • Accepted : 2012.01.04
  • Published : 2012.02.29
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Cigarette smoke induced release of iron could alter iron metabolism in the lungs of chronic smokers and contribute to the increase in the total oxidative burden on the lungs of smokers. In previous studies, ferritin levels of bronchoalveolar lavage fluid in smokers were elevated. The aim of the present study was to investigate the relationship between serum ferritin concentration, smoking and lung function in Korean people. Methods: This study was based on the data acquired in the second year (2008) of the Forth National Health and Nutrition Examination Survey that was conducted from 2007 to 2009. The analysis included 2,244 subjects who were older than 20 years and had complete data from both lung function test and serum ferritin concentration. Among participants, 1,076 were male and 1,168 were female. Results: Mean serum ferritin concentrations in males were $120.3{\pm}80.1{\mu}g/L$ and $47.9{\pm}39.8{\mu}g/L$ in females. There were no differences in serum ferritin concentrations between non-smokers and smokers after adjusting for age, body mass index, and amounts of alcohol. Serum ferritin concentrations were associated with smoking amounts by simple linear regression but not associated with smoking amounts after adjustment with age, body mass index, and amounts of alcohol in both males and females. Lung function was not associated with serum ferritin concentrations. Conclusion: Our data suggested that serum ferritin concentrations are not related with smoking and lung function.

Keywords

References

  1. Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985;64:111-26. https://doi.org/10.1289/ehp.8564111
  2. Lapenna D, de Gioia S, Mezzetti A, Ciofani G, Consoli A, Marzio L, et al. Cigarette smoke, ferritin, and lipid peroxidation. Am J Respir Crit Care Med 1995;151: 431-5. https://doi.org/10.1164/ajrccm.151.2.7842202
  3. You SA, Wang Q. Ferritin in atherosclerosis. Clin Chim Acta 2005;357:1-16. https://doi.org/10.1016/j.cccn.2005.02.001
  4. Arosio P, Levi S. Ferritin, iron homeostasis, and oxidative damage. Free Radic Biol Med 2002;33:457-63. https://doi.org/10.1016/S0891-5849(02)00842-0
  5. Moreno JJ, Foroozesh M, Church DF, Pryor WA. Release of iron from ferritin by aqueous extracts of cigarette smoke. Chem Res Toxicol 1992;5:116-23. https://doi.org/10.1021/tx00025a020
  6. Ghio AJ, Hilborn ED, Stonehuerner JG, Dailey LA, Carter JD, Richards JH, et al. Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect. Am J Respir Crit Care Med 2008;178: 1130-8. https://doi.org/10.1164/rccm.200802-334OC
  7. Hughes K, Choo M, Kuperan P, Ong CN, Aw TC. Cardiovascular risk factors in relation to cigarette smoking: a population-based survey among Asians in Singapore. Atherosclerosis 1998;137:253-8. https://doi.org/10.1016/S0021-9150(97)00268-2
  8. Leggett BA, Brown NN, Bryant SJ, Duplock L, Powell LW, Halliday JW. Factors affecting the concentrations of ferritin in serum in a healthy Australian population. Clin Chem 1990;36:1350-5.
  9. Cafolla A, Dragoni F, Girelli G, Tosti ME, Costante A, Pastorelli D, et al. Folate status in Italian blood donors: relation to gender and smoking. Haematologica 2000; 85:694-8.
  10. Lee BK, Kim Y, Kim YI. Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean National Health and Nutrition Examination Survey 2008. Metabolism 2011;60:1416-24. https://doi.org/10.1016/j.metabol.2011.02.008
  11. Thompson AB, Bohling T, Heires A, Linder J, Rennard SI. Lower respiratory tract iron burden is increased in association with cigarette smoking. J Lab Clin Med 1991;117:493-9.
  12. Wesselius LJ, Flowers CH, Skikne BS. Alveolar macrophage content of isoferritins and transferrin. Comparison of nonsmokers and smokers with and without chronic airflow obstruction. Am Rev Respir Dis 1992; 145:311-6. https://doi.org/10.1164/ajrccm/145.2_Pt_1.311
  13. Touitou Y, Proust J, Carayon A, Klinger E, Nakache JP, Huard D, et al. Plasma ferritin in old age. Influence of biological and pathological factors in a large elderly population. Clin Chim Acta 1985;149:37-45. https://doi.org/10.1016/0009-8981(85)90271-2
  14. Kim SH, Kim JS, Shin HS, Keen CL. Influence of smoking on markers of oxidative stress and serum mineral concentrations in teenage girls in Korea. Nutrition 2003;19:240-3. https://doi.org/10.1016/S0899-9007(02)01002-X

Cited by

  1. 저열량 생즙 식이가 성인의 혈청 페리틴 농도에 미치는 영향 vol.26, pp.4, 2012, https://doi.org/10.7856/kjcls.2015.26.4.661