Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Detection and Prognostic Analysis of Serum Protein Expression in Esophageal Squamous Cell Cancer

  • Jiang, Hong (Key Laboratory of Thoracic Tumor Diagnosis (Esophagus, Lung) and Treatment Technology Research, Department of Thoracic Surgery, Zhejiang Cancer Hospital) ;
  • Wang, Xiao-Hong (Department of Chemotherapy, Zhejiang Cancer Hospital) ;
  • Yu, Xin-Min (Department of Chemotherapy, Zhejiang Cancer Hospital) ;
  • Zheng, Zhi-Guo (Zhejiang Cancer Institute)
  • Published : 2012.04.30
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Abstract

Objective: To assess differences in serum proteins in esophageal squamous cell carcinoma patients. Methods: 144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads. Follow-up allowed the relations between serum proteins and prognosis to be analyzed. Results: A total of 93 protein peaks were detected (molecular weight range: 1500-30000), 10 demonstrating statistically significant differences. There were no differences in protein peaks between 92 patients with a survival more than 2 years and 52 patients with survival less than 2 years. There were two significantly different protein peaks between 45 stage II patients with a survival more than 2 years and 14 stage II patients with survival less than 2 years. There was one significantly different protein peak between 22 stage III patients with a survival more than 2 years and 29 stage III patients with survival less than 2 years. Conclusion: Differences of serum proteins in esophageal squamous cell carcinoma are related to prognosis of patients. The protein fingerprint can be helpful for clinical diagnosis and treatment.

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