Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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MTHFR C677T Polymorphism and Colorectal Cancer Risk in Asians, a Meta-analysis of 21 Studies

  • Yang, Zhen (Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University) ;
  • Zhang, Xie-Fu (Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University) ;
  • Liu, Hong-Xiang (Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University) ;
  • Hao, Yong-Shun (Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University) ;
  • Zhao, Chun-Lin (Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University)
  • Published : 2012.04.30
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Abstract

Background: Previous studies concerning the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer risk in Asian populations generated conflicting results. A meta-analysis was therefore performed to allow a more reliable estimate of any link. Methods: Relevant studies concerning the association between the MTHFR C677T polymorphism and risk of colorectal cancer were included into this meta-analysis. The quality of the studies was assessed according to a predefined scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined for this gene-disease association using fixed or random effect models according to the heterogeneity between included studies. Results: Finally, 21 studies with a total of 6692 cases and 8266 controls were included. Meta-analyses showed that there was an obvious association of the MTHFR 677T allele with decreased risk of colorectal cancer (OR = 0.91, 95%CI=0.85-0.98, P=0.011). Subgroup analyses by country further identified this association, with dietary folate as the main source of heterogeneity. Conclusion: The MTHFR 677T allele is associated with a lower risk of colorectal cancer in Asian populations, and there is effect modification by population plasma folate.

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References

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