개에서 Medetomidine-Ketamine-Butorphanol과 Xylazine-Ketamine-Butorphanol의 마취 효과 및 심폐에 미치는 영향

Anesthetic and Cardiorespiratory Effects of Medetomidine-Ketamine-Butorphanol and Xylazine-Ketamine-Butorphanol in Dogs

  • 이태훈 (충남대학교 수의과대학.동물의과학연구소) ;
  • 이재연 (충남대학교 수의과대학.동물의과학연구소) ;
  • 정성목 (충남대학교 수의과대학.동물의과학연구소) ;
  • 김명철 (충남대학교 수의과대학.동물의과학연구소)
  • Lee, Tae-Hun (Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Jae-Yeon (Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong-Mok (Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myung-Cheol (Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University)
  • 심사 : 2012.06.18
  • 발행 : 2012.06.30

초록

Medetomidine과 xylazine은 수의 임상에서 많이 이용되고 있는 마취약물이다. Medetomidine-ketamine-butorphanol과 xylazine-ketamine-butorphanol의 개에 미치는 마취효과와 심폐 효과를 비교 연구하였다. Medetomidine-ketamine-butorphanol를 MKB군으로 xylazine-ketamine-butorphanol를 XKB군으로 분류하고 각각 5두의 개를 4주간의 휴약기간을 거쳐 실험하였다. 각각의 군에서 마취효과 점수는 자세와 진통에 대한 반응을 통해 평가하였고, 마취 시간은 XKB군 ($87.4{\pm}18.9$분)이 MKB군 ($62.6{\pm}15.0$분)에 비하여 유의성 있게 높은 시간의 결과를 보였다. 하지만, 기타 심폐 효과에서는 두 군 사이에 통계적으로 유의성 있는 차이를 보이지 않았다. 하지만 MKB군에서는 서맥을 보였으므로, 마취 모니터링 시 주의하여야 한다. 만약 서맥의 위험이 있는 환자라면 MKB 합제는 선택을 안 하는 것이 요구된다. 결론적으로, XKB군에서 더 긴 마취시간과 더 적은 부작용을 보였으며, MKB 합제 약물은 XKB군에 비하여 특별한 장점이 없으므로 XKB 합제가 더욱 유용한 것으로 판단하였다. 하지만 XKB군과 MKB군 모두에서 적절한 체온유지와 산소공급이 필요하다.

This study examined the anesthetic and cardiopulmonary effects of xylazine or medetomidine in combination with ketamine-butorphanol in dogs. Five dogs were used in both the medetomidine-ketamine-butorphanol (MKB) group and the xylazine-ketamine-butorphanol (XKB) group. The procedures for the two groups were performed 4 weeks apart. MKB group showed a shorter duration for anesthesia than XKB group. Other factors were not statistically significant between the two groups. The MKB group showed signs of bradycardia, therefore cautious patient monitoring is necesessary. The XKB showed a longer anesthetic time and less adverse effects, however the MKB combination was more expensive and had less advantages. In conclusion, the results suggested the recommended use of both MKB and XKB in procedures that need approximately 50 minutes. If patients have a risk of bradycardia, one should be cautious of using a medetomidine-xylazine-butorphanol combination. Both MKB and XKB did not have much adverse effects; however MKB did not have advantages when compared to XKB. Therefore, XKB may be more effective when compared to MKB.

키워드

참고문헌

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