Mycobiology

The Korean Society of Mycology (한국균학회)
권호 표지
DOI QR코드

DOI QR Code

Nonanoic Acid, an Antifungal Compound from Hibiscus syriacus Ggoma

  • Jang, Yun-Woo (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Jung, Jin-Young (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Lee, In-Kyoung (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Kang, Si-Yong (Radiation Breeding Research Team, Advanced Radiation Technology Institute-Jeongeup, Korea Atomic Energy Research Institute) ;
  • Yun, Bong-Sik (Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University)
  • Received : 2012.06.18
  • Accepted : 2012.06.19
  • Published : 2012.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The root of Hibiscus syriacus (Malvaceae) has been used for treatment of fungal diseases such as tinea pedis (athlete's foot). In this study, we investigated the antifungal constituent of the root of Hibiscus syriacus Ggoma, which was produced by a mutation breeding using gamma ray irradiation, and compared the antifungal activity of H. syriacus Ggoma and its parent type. According to the results, the methanolic extract of H. syriacus Ggoma exhibited four times higher antifungal activity than its parent type against Trichophyton mentagrophytes. Following purification through various column chromatographies, the antifungal substance was identified as nonanoic acid on the basis of spectroscopic analysis.

Keywords

References

  1. Hsu HY, Chen YP, Shen SJ, Hsu CS, Chen CC, Chang HC. Oriental materia medica: a concise guide. Taiwan: Oriental Healing Arts Institute; 1986. p. 503-4.
  2. Huang KC. The pharmacology of Chinese herbs. Tokyo: CRC Press; 1993. p. 193-4.
  3. Yun BS, Ryoo IJ, Lee IK, Yoo ID. Hibispeptin B, a novel cyclic peptide from Hibiscus syriacus. Tetrahedron 1998;54: 15155-60. https://doi.org/10.1016/S0040-4020(98)00967-3
  4. Yun BS, Ryoo IJ, Lee IK, Park KH, Choung DH, Han KH, Yoo ID. Two bioactive pentacyclic triterpene esters from the root bark of Hibiscus syriacus. J Nat Prod 1999;62:764-6. https://doi.org/10.1021/np9804637
  5. Yoo ID, Yun BS, Lee IK, Ryoo IJ, Choung DH, Han KH. Three naphthalenes from root bark of Hibiscus syriacus. Phytochemistry 1998;47:799-802. https://doi.org/10.1016/S0031-9422(97)00674-2
  6. Song HS, Park IS, Lim YT, Kim JK, Lee GJ, Kim DS, Lee SJ, Kang SY. A dwarf type new rose of Sharon variety, "Ggoma" developed by a mutation breeding. Korean J Breed 2006;38:293-4.
  7. Aneja M, Gianfagna TJ, Hebbar PK. Trichoderma harzianum produces nonanoic acid, an inhibitor of spore germination and mycelial growth of two cacao pathogens. Physiol Mol Plant Pathol 2005;67:304-7. https://doi.org/10.1016/j.pmpp.2006.05.002