Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
권호 표지
DOI QR코드

DOI QR Code

The Effects of Pilocarpine in Patients with Orofacial Movement Disorder

구강안면운동장애에 대한 필로카핀의 적용

  • Jeong, Sung-Hee (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ok, Soo-Min (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Huh, Joon-Young (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ko, Myung-Yun (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ahn, Yong-Woo (Department of Oral Medicine, School of Dentistry, Pusan National University)
  • 정성희 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 옥수민 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 허준영 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 고명연 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 안용우 (부산대학교 치의학전문대학원 구강내과학교실)
  • Received : 2012.04.16
  • Accepted : 2012.05.28
  • Published : 2012.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Orofacial movement disorders (OMD) are uncontrolled movement of the muscles involving the face, tongue, lip and mandible. Due to variable oral and lingual muscles affected, the patients with OMD are interfered with the appropriate performance such as chewing, swallowing and talking. In this study, there are 4 OMD cases with oral dryness that saliva flow rate is decreased or not. The symptoms are improved after oral administration of pilocarpine to 4 patients with OMD. Therefore, we suggest that objective or subjective oral dryness could be etiologic factor in OMD and pilocarpine could be regarded as medication for OMD.

하악 및 구강주위근육의 조절되지 않는 움직임으로 정의 되는 구강안면운동장애(orofacial movement disorder, OMD)는 노인층에서 많이 발생하며 그 원인이 아직 정확히 밝혀지지 않고 치료방법 또한 다양하다. 임상적 특징을 분석하고 치료방법을 연구한 자료는 많이 있으나 타액분비와 OMD의 상관관계에 대한 구체적인 연구는 아직 없다. 본 연구에서는 부산대학교치과병원 구강내과에 내원한 OMD 환자 중 구강건조감을 호소한 4명의 환자를 증례로 하여 필로카핀(pilocarpine)을 경구로 투여한 후 OMD 증상의 변화를 관찰하였다. 연구결과 타액분비량의 저하를 보여 구강건조증으로 진단된 증례와 정상타액분비량을 보이는 증례 모두에서 필로카핀의 경구투여 후 OMD증상의 개선을 보였다. 따라서 향후 OMD와 구강건조증의 상관관계에 대한 추가적인 연구가 필요할 것으로 사료된다.

Keywords

References

  1. Lee KH. Oromandibular dystonia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:491-496. https://doi.org/10.1016/j.tripleo.2007.04.001
  2. Viswanath A, Gordon SM. Two cases of oromandibular dystonia referred as temporomandibular joint disorder. Grand Rounds 2012;12:1-5. https://doi.org/10.1102/1470-5206.2012.0001
  3. Michelotti A, Silva R, Paduano S, Cimino R, Farella M. Oromandibular dystonia and hormonal factors: Twelve years follow-up of a case report. J Oral Rehabil 2009;36:916-921. https://doi.org/10.1111/j.1365-2842.2009.02007.x
  4. Rajabally YA, Farrell D, Messios N. Oro-mandibular dystonia in a case of multiple sclerosis with capsular plaque. Eur Neurol 2003;49:190-191. https://doi.org/10.1159/000069084
  5. Jankovic J. Tardive syndromes and other druginduced movement disorders. Clin Neuropharmacol 1995;18:197-214. https://doi.org/10.1097/00002826-199506000-00001
  6. van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS. The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: The curacao extrapyramidal syndromes study II. Schizophr Res 1997;26:235-242. https://doi.org/10.1016/S0920-9964(97)00058-3
  7. Shin-Woong Kang, Hee-Hoon Choi, Ki-Suk Kim, Mee-Eun Kim. Clinical features of oromandibular dystonia. Kor J Oral Med 2011;36:169-176.
  8. Balasubramaniam R, Ram S. Orofacial movement disorders. Oral Maxillofac Surg Clin North Am 2008;20:273-85 https://doi.org/10.1016/j.coms.2007.12.010
  9. Blanchet PJ, Rompre PH, Lavigne GJ, Lamarche C. Oral dyskinesia: A clinical overview. Int J Prosthodont 2005;18:10-19.
  10. 유지원, 홍성주, 배국진, 윤창륙, 안종모. 보툴리눔 톡신을 이용한 구강하악 근긴장이상증의 치료 증례. 대한구강내과학회지 2009;34:421-427.
  11. Blanchet PJ, Abdillahi O, Beauvais C, Rompre PH, Lavigne GJ. Prevalence of spontaneous oral dyskinesia in the elderly: A reappraisal. Mov Disord 2004;19:892-896. https://doi.org/10.1002/mds.20130
  12. Maestre-Ferrin L, Burguera JA, Penarrocha-Diago M, Penarrocha-Diago M. Oromandibular dystonia: A dental approach. Med Oral Patol Oral Cir Bucal 2010;15:e25-7.
  13. Sankhla C, Lai EC, Jankovic J. Peripherally induced oromandibular dystonia. J Neurol Neurosurg Psychiatry 1998;65:722-728. https://doi.org/10.1136/jnnp.65.5.722
  14. Clark GT, Ram S. Four oral motor disorders: Bruxism, dystonia, dyskinesia and drug-induced dystonic extrapyramidal reactions. Dent Clin North Am 2007;51:225-43 https://doi.org/10.1016/j.cden.2006.09.002
  15. Goldman JG, Comella CL. Treatment of dystonia. Clin Neuropharmacol 2003;26:102-108. https://doi.org/10.1097/00002826-200303000-00010
  16. Guggenheimer J, Moore PA. Xerostomia: Etiology, recognition and treatment. J Am Dent Assoc 2003;134:61-9 https://doi.org/10.14219/jada.archive.2003.0018
  17. Longman LP, McCracken CF, Higham SM, Field EA. The clinical assessment of oral dryness is a significant predictor of salivary gland hypofunction. Oral Dis 2000;6:366-370.
  18. Field EA, Longman LP, Bucknall R, Kaye SB, Higham SM, Edgar WM. The establishment of a xerostomia clinic: A prospective study. Br J Oral Maxillofac Surg 1997;35:96-103. https://doi.org/10.1016/S0266-4356(97)90683-5
  19. Heft MW, Baum BJ. Unstimulated and stimulated parotid salivary flow rate in individuals of different ages. J Dent Res 1984;63:1182-1185. https://doi.org/10.1177/00220345840630100101
  20. 오정규, 김연중, 고홍섭. 구강건조증 환자의 임상적 특징에 관한 연구. 대한구강내과학회지 2001;26: 331-343.
  21. 김지현, 박주현, 권정승, 안형준. 구강건조증에 대한 필로카핀 구강양치액의 효과. 대한구강내과학회지 2011;36:21-24.
  22. Cavalheiro EA. The pilocarpine model of epilepsy. Ital J Neurol Sci 1995;16:33-37. https://doi.org/10.1007/BF02229072
  23. Ferhat L. Potential role of drebrin a, an f-actin binding protein, in reactive synaptic plasticity after pilocarpine-induced seizures: Functional implications in epilepsy. Int J Cell Biol 2012:4743-51.