Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

  • Kim, Hyo-Jeong (Department of Bioscience and Biotechnology, Sejong University) ;
  • Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan College) ;
  • Lee, Sung-Won (Department of Bioscience and Biotechnology, Sejong University) ;
  • Yun, Dae-Sun (Department of Bioscience and Biotechnology, Sejong University) ;
  • Kim, Ji-Yeon (School of Life Science & Biotechnology, Korea University) ;
  • Shin, Kwang-Soon (Department of Food & Biotechnology, Kyonggi University) ;
  • Park, Se-Ho (School of Life Science & Biotechnology, Korea University) ;
  • Hong, Seok-Mann (Department of Bioscience and Biotechnology, Sejong University)
  • Received : 2011.09.03
  • Accepted : 2011.10.04
  • Published : 2012.06.30
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Abstract

Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HKvaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the upregulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

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