Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Screening of aldose reductase inhibitory activity of white-color natural products

화이트 칼라소재의 알도즈 환원효소 억제작용 탐색

  • Mok, So-Youn (Department of Integrative Plant Science, Chung-Ang University) ;
  • Shin, Hyun-Cheol (Southern Forest Research Center, Korea Forest Research Institute) ;
  • Lee, Sang-Hyun (Department of Integrative Plant Science, Chung-Ang University)
  • 목소연 (중앙대학교 식물시스템과학과) ;
  • 신현철 (국립산림과학원 남부산림연구소) ;
  • 이상현 (중앙대학교 식물시스템과학과)
  • Received : 2011.12.27
  • Accepted : 2012.03.23
  • Published : 2012.03.31
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Abstract

The purpose of this study was to evaluate the potential of naturally occurring aldose reductase (AR) inhibitors from white-color natural products (Aruncus dioicus var. kamtschaticus, Chionanthus retusa, Cosmos bipinnatus, Hibiscus syriacus, Hydrangea paniculata, Magnolia denudata, Prunus padus, Robinia pseudo-accacia, Rhododendron mucronulatum for. albiflorum, Spiraea blumei, and Spiraea prunifolia var. simpliciflora). The MeOH extract of white-color natural products were tested on rat lens AR inhibition in vitro. Among them, the MeOH extract of R. mucronulatum for. albiflorum showed highest inhibition on AR ($IC_{50}$ value, 1.07 ${\mu}g/ml$). These results suggested that R. mucronulatum for. albiflorum, a white-color natural product, could be a useful resource in the development of a novel AR inhibitory agent against diabetic complications.

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References

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