Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Cytotoxicity of Methanol Extracts from Cudrania tricuspidata Bureau

꾸지뽕나무 메탄올 추출물의 세포독성

  • Choi, So-Ra (Resources and Food Division, Chonbuk Agricultural Research & Extension Services) ;
  • You, Dong-Hyun (Specialization Crop Research Institute, Chonbuk Agricultural Research & Extension Services) ;
  • Jang, Ik (Specialization Crop Research Institute, Chonbuk Agricultural Research & Extension Services) ;
  • Ahn, Min-Sil (Resources and Food Division, Chonbuk Agricultural Research & Extension Services) ;
  • Song, Eun-Ju (Resources and Food Division, Chonbuk Agricultural Research & Extension Services) ;
  • Seo, Sang-Young (Resources and Food Division, Chonbuk Agricultural Research & Extension Services) ;
  • Choi, Min-Kyung (Resources and Food Division, Chonbuk Agricultural Research & Extension Services) ;
  • Kim, Young-Sun (Resources and Food Division, Chonbuk Agricultural Research & Extension Services) ;
  • Kim, Myung-Kon (College of Agriculture and Life Science, Chonbuk National University) ;
  • Choi, Dong-Geun (College of Agriculture and Life Science, Chonbuk National University)
  • 최소라 (전라북도농업기술원 자원식품과) ;
  • 유동현 (전라북도농업기술원 특화작목연구소) ;
  • 장익 (전라북도농업기술원 특화작목연구소) ;
  • 안민실 (전라북도농업기술원 자원식품과) ;
  • 송은주 (전라북도농업기술원 자원식품과) ;
  • 서상영 (전라북도농업기술원 자원식품과) ;
  • 최민경 (전라북도농업기술원 자원식품과) ;
  • 김영선 (전라북도농업기술원 자원식품과) ;
  • 김명곤 (전북대학교 농업생명과학대학) ;
  • 최동근 (전북대학교 농업생명과학대학)
  • Received : 2012.03.26
  • Accepted : 2012.05.18
  • Published : 2012.06.30
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Abstract

In order to develop as a natural source of anticancer materials of Cudrania tricuspidata, the cytotoxicity of methanol extracts by harvesting parts and times against 8 cell lines including 293 (normal kidney cells) and A-431 (epidermoid carcinoma cells) were investigated using MTT assay. All harvesting parts had hardly cytotoxicity against 293. And methanol extracts of stem bark and root bark showed very high cytotoxicities against 7 cancer cell lines. The cytotoxicity was the highest against HeLa (cervix adenocarcinoma cells) and followed by MCF-7 (breast adenocarcinoma cells), AGS (stomach adenocarcinoma cells), HT-29 (colon adenocarcinoma cells), HepG2 (hepatoblastoma cells), A549 (lung carcinoma cells) and A-431. By the way, leaf extract had a cytotoxicity against only AGS and ripe fruit extract had no cytotoxicity. Among harvesting times, the cytotoxicity of root bark were high from April to September but that of stem bark showed a little difference. These results showed that anticancer activities of Cudrania tricuspidata extracts were eventful changes by harvesting parts and times.

Keywords

References

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