Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Chinemys reevesii on Lipopolysaccaride-indused Inflammatory Reactions

구판의 LPS로 유도된 염증 반응 억제 효과

  • Baek, Young-Mi (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Choi, Jung-Yen (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Lee, Cheol-Woo (East-West Comparing Oriental Medicine Society) ;
  • Jeon, Young-Seok (East-West Comparing Oriental Medicine Society) ;
  • Han, Jin-Taek (East-West Comparing Oriental Medicine Society) ;
  • Jang, Sung-Il (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
  • 백영미 (대전대학교 둔산한방병원 동서암센터) ;
  • 최정은 (대전대학교 둔산한방병원 동서암센터) ;
  • 이철우 (동서비교한의학회) ;
  • 전영석 (동서비교한의학회) ;
  • 한진택 (동서비교한의학회) ;
  • 장성일 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Received : 2011.12.09
  • Accepted : 2012.02.17
  • Published : 2012.02.25
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Abstract

This study is to investigate the effects of Chinemys reevesii (CR) on allergic inflammation mechanism related chronic dermatitis. To investigate the effects of CR, we study inhibitory effect of CR on the levels of pro-inflammatory cytokines released from RAW 264.7 cell stimulated with lipopolysaccaride (LPS), and EoL-1, THP-1, Jutkat cell stimulated with Dermatophagoides pteronyssinus (DP), and LPS induced acute inflammatory BALB/c mouse model. CR reduced the levels of IL-$1{\beta}$ released from RAW 264.7 cell stimulated with LPS at 20 ug/ml, 10 ug/ml concentration. CR significantly reduced the levels of MCP-1 released from EoL-1 cell, IL-6 from THP-1 cell, and IL-4, IL-5, TNF-${\alpha}$ from Jutkat cell stimulated with DP at all the concentration. CR significantly reduced the levels of TNF-${\alpha}$, IL-6, IL-$1{\beta}$, in LPS induced inflammatory BALB/c mouse model, in a dose-dependent manner. These results suggested that CR has suppressive effects on pro-inflammatory cytokines in various inflammation related cell lines through the regulation of immune system. CR could be a therapeutic agent for treatment of chronic inflammatory dermatitis in the future.

Keywords

References

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