Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effects of Bee Venom on Papain-induced Osteoarthritis in an Animal Model

봉독이 Papain으로 유도된 골관절염 동물 모델에 미치는 영향

  • An, Hyun-Jin (Department of Pathology, Catholic University of Daegu, College of Medicine) ;
  • Lee, Chong-Kee (Department of Immunology, Catholic University of Daegu, College of Medicine) ;
  • Park, Ji-Hyun (Department of Pathology, Catholic University of Daegu, College of Medicine) ;
  • Kim, Kyung-Hyun (Department of Pathology, Catholic University of Daegu, College of Medicine) ;
  • Lee, Woo-Ram (Department of Pathology, Catholic University of Daegu, College of Medicine) ;
  • Park, In-Young (Department of Pathology, Catholic University of Daegu, College of Medicine) ;
  • Han, Sang-Mi (Department of Agricultural Biology, National Institute of Agricultural Science and Technology) ;
  • Lee, Kwang-Gill (Department of Agricultural Biology, National Institute of Agricultural Science and Technology) ;
  • Park, Kwan-Kyu (Department of Pathology, Catholic University of Daegu, College of Medicine)
  • 안현진 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 이종기 (대구가톨릭대학교 의과대학 면역학교실) ;
  • 박지현 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 김경현 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 이우람 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 박인영 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 한상미 (농촌진흥청 농업과학기술원 농업생물부) ;
  • 이광길 (농촌진흥청 농업과학기술원 농업생물부) ;
  • 박관규 (대구가톨릭대학교 의과대학 병리학교실)
  • Received : 2012.02.24
  • Accepted : 2012.04.18
  • Published : 2012.06.30
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Abstract

Osteoarthritis (OA) is an age-related joint disease characterized by degradation of articular cartilage and its association with chronic pain. Purified Bee venom (PBV) has been traditionally used to the treatment for inflammatory diseases. The purpose of the current study is to examine whether PBV regulates the pro-inflammation against a mouse model of knee OA induced by papain. We studied the effect of PBV on papain-induced OA in the knee joints of mice. Mice were split into following groups: normal control, papain induced OA, OA treated with PBV, OA treated with meloxicam as positive control. Proteoglycan deposition was analyzed by safranin O-fast green staining and H&E staining. Papain injection significantly degraded the proteoglycan in OA mice at 42 days. Cartilage proteoglycan density was significantly higher in PBV treated OA group than those of the positive control groups. These results demonstrate that PBV efficiently suppresses pathological processes in an OA model. Thus, PBV could be a potential therapeutic strategy for the treatment of OA.

Keywords

References

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