Korean Journal of Schizophrenia Research (대한조현병학회지)

Korean Society for Schizophrenia Research (대한조현병학회)
권호 표지

Working Memory Deficits in Ultra-High Risk for Psychosis and Schizophrenia

조현병 및 정신증 고위험군에서의 작업기억 손상

  • Jeon, Im Hong (Department of Psychiatry, Yonsei University College of Medicine, Severance Mental Health Hospital) ;
  • Park, Jong Suk (Department of Psychiatry, Yonsei University College of Medicine, Severance Mental Health Hospital) ;
  • Park, Jin Young (Department of Psychiatry, Yonsei University College of Medicine, Severance Mental Health Hospital) ;
  • Cho, Hye Hyun (Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Koo, Se Jun (Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Lee, Eun (Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • An, Suk Kyoon (Department of Psychiatry, Yonsei University College of Medicine, Severance Mental Health Hospital) ;
  • Yoo, Sun Kook (Department of Medical Engineering, Yonsei University College of Medicine)
  • 전임홍 (연세대학교 의과대학 세브란스정신건강병원 정신건강의학과) ;
  • 박종석 (연세대학교 의과대학 세브란스정신건강병원 정신건강의학과) ;
  • 박진영 (연세대학교 의과대학 세브란스정신건강병원 정신건강의학과) ;
  • 조혜현 (연세대학교 의과대학 의학행동과학연구소 정동 및 신경과학섹션) ;
  • 구세준 (연세대학교 의과대학 의학행동과학연구소 정동 및 신경과학섹션) ;
  • 이은 (연세대학교 의과대학 의학행동과학연구소 정동 및 신경과학섹션) ;
  • 안석균 (연세대학교 의과대학 세브란스정신건강병원 정신건강의학과) ;
  • 유선국 (연세대학교 의과대학 의공학교실)
  • Received : 2012.08.15
  • Accepted : 2012.09.10
  • Published : 2012.10.30

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Abstract

Objectives : The aim of this study was to investigate whether verbal and spatial working memory functions were impaired not only in patients with schizophrenia but also in people at ultra-high risk for first-episode psychosis. Methods : Twenty-five patients (M 13, F 12) with schizophrenia (SPR), 21 people at ultra-high risk for psychosis (UHR)(M 10, F 11) and 19 normal controls (NC)(M 10, F 9) were recruited. The working memory was assessed by using the verbal and spatial n-back test. The working memory load increased incrementally from the 0-back to the 3-back condition. Results : SPR performed significantly lower than NC and UHR in terms of hit rates of verbal and spatial n-back test. UHR subjects conducted significantly lower than NC and higher in trend-level than SPR in terms of hit rates of verbal and spatial n-back test. These differences were derived from the high working memory load (2-back and 3-back), not from the low working memory load (0-back and 1-back). There was no significant difference between the verbal and spatial n-back test across the three groups. Conclusion : These findings suggest that verbal and spatial working memory dysfunction may be general rather than differential in terms of stimuli modality, and this working memory deficit may be an important trait factor in schizophrenia.

Keywords

Acknowledgement

이 논문은 2010년도 정부(교육과학기술부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2010-0026833).