Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Change of Cerebrovascular Reactivity by Prandial State in Women with Migraine without Aura: Transcranial Doppler Ultrasonography (TCD) with Breath-Holding Method

두개경유도플러초음파를 이용한 성인 여성 무조짐편두통 환자의 식사 상태에 따른 뇌혈관반응성 변화

  • Park, Jeong-Ho (Department of Neurology, College of Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Park, Sun-Ah (Department of Neurology, College of Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Lee, Tae-Kyeong (Department of Neurology, College of Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Sung, Ki-Bum (Department of Neurology, College of Medicine, Soonchunhyang University Bucheon Hospital)
  • 박정호 (순천향대학교 의과대학 부천병원 신경과학교실) ;
  • 박선아 (순천향대학교 의과대학 부천병원 신경과학교실) ;
  • 이태경 (순천향대학교 의과대학 부천병원 신경과학교실) ;
  • 성기범 (순천향대학교 의과대학 부천병원 신경과학교실)
  • Received : 2011.09.11
  • Accepted : 2011.12.28
  • Published : 2012.06.30
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Abstract

Background: Migraine patients can be sensitive to external or internal stimuli, such as light, noise, or hormonal changes. Using transcranial Doppler ultrasonography (TCD) with breath-holding method, we evaluated the changes of cerebrovascular reactivity (CVR) to hypercapnia in women with migraine without aura between fasting and postprandial period. Methods: Twelve women with migraine without aura and the same number of age and sex-matched healthy controls with no significant history of headache participated in this study. Using TCD examinations, we studied mean flow velocity in middle cerebral artery with better temporal window. Each subject was examined consecutively before and after a standard meal, together with serum glucose level and blood pressure. CVR was evaluated with breath-holding index (BHI). Results: Postprandial-BHI (mean+SD) was significantly higher than fasting-BHI (mean+SD) in patients group but not in controls (in patient group; postprandial-BHI=1.38, fasting-BHI=1.08, in control group; postprandial-BHI=1.25, fasting-BHI=1.18, P=0.021 and 0.239, respectively). After meal, serum glucose level was significantly enhanced but blood pressure was not in both groups. Serum glucose level of patients showed a tendency of mild positive correlation with BHIs (${\gamma}$=0.448, P=0.032). Conclusions: Although exact mechanisms are unclear, cerebrovascular reactivity of some women with migraine without aura may be influenced by prandial state.

Keywords

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