Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Predictors of Long-Term Survival in Acute Coronary Syndrome Patients With Left Ventricular Dysfunction After Percutaneous Coronary Intervention

  • Lee, Doo Hwan (The Heart Center of Chonnam National University Hospital) ;
  • Jeong, Myung Ho (The Heart Center of Chonnam National University Hospital) ;
  • Rhee, Jung Ae (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Choi, Jin Su (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Lee, Ki Hong (The Heart Center of Chonnam National University Hospital) ;
  • Lee, Min Goo (The Heart Center of Chonnam National University Hospital) ;
  • Sim, Doo Sun (The Heart Center of Chonnam National University Hospital) ;
  • Park, Keun-Ho (The Heart Center of Chonnam National University Hospital) ;
  • Yoon, Nam Sik (The Heart Center of Chonnam National University Hospital) ;
  • Yoon, Hyun Ju (The Heart Center of Chonnam National University Hospital) ;
  • Kim, Kye Hun (The Heart Center of Chonnam National University Hospital) ;
  • Park, Hyung Wook (The Heart Center of Chonnam National University Hospital) ;
  • Hong, Young Joon (The Heart Center of Chonnam National University Hospital) ;
  • Kim, Ju Han (The Heart Center of Chonnam National University Hospital) ;
  • Ahn, Youngkeun (The Heart Center of Chonnam National University Hospital) ;
  • Cho, Jeong Gwan (The Heart Center of Chonnam National University Hospital) ;
  • Park, Jong Chun (The Heart Center of Chonnam National University Hospital) ;
  • Kang, Jung Chaee (The Heart Center of Chonnam National University Hospital)
  • Published : 2012.10.31
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Abstract

Background and Objectives: Predictive factors of mortality in acute coronary syndrome (ACS) patients with left ventricular dysfunction were analyzed during 5-year clinical follow-up after percutaneous coronary intervention (PCI). Subjects and Methods: A total of 329 ACS consecutive patients ($64.6{\pm}11.3$ years, 227 males) who underwent PCI from January 2001 to March 2006 were followed for 5 years. All patients had lower than 40% of left ventricular ejection fraction (LVEF). Patients were divided into Group I (survived longer than 5-years: n=130, 101 males) and Group II (survived shorter than 5 years: n=199, 126 males). Results: The cumulative survival rate was 88.0% at 1 month, 78.0% at 6 months, 75.0% at 1 year, 67.0% at 2 years, 62.0% at 3 years, 57.0% at 4 years and 40% at 5-years. Group II was older ($61.6{\pm}11.2$ years vs. $66.4{\pm}11.4$ years, p<0.001), and showed higher prevalence of female gender (28.4% vs. 36.7%, p=0.006) and lower LVEF ($35.3{\pm}5.2$ vs. $33.6{\pm}5.6$) than Group I. The independent predictors for mortality were LVEF <30% {odds ratio (OR)=1.793, 95% confidence interval (CI): 1.234-2.452, p=0.002}, serum creatinine >3.0 mg/dL (OR=2.455, 95% CI: 1.306-4.614, p=0.005), older than 65 years (OR=1.594, 95% CI: 1.152-2.206, p=0.005), and female gender (OR=1.524, 95% CI: 1.090-2.130, p=0.014). Conclusion: Five-year survival rate was 40% in ACS patients with left ventricular dysfunction, and the predictors for mortality were low LVEF, high serum creatinine, old age, and female gender.

Keywords

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