Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

The Biological Safety Study of Non-PVC Material Available for Infusion Tube

Non-PVC계 재료를 적용한 수액세트용 튜브의 생물학적 안전성에 관한 연구

  • Published : 2012.12.01
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Abstract

Infusion tube set made from PVC contains DEHP as plasticizer in order to provide elastic property. But the release of this DEHP from PVC tube occurs various clinical undesired effects in living body. In this study, we tried to develop non-PVC infusion tube using polybutadiene based polymer and styrene based copolymer. After processing 2 kinds of tube using above material, the biological safety was confirmed. As control, commercialized tubes(made by Hanaco(China) and JMS(Japan)) was adapted. From the results of safety test, we concluded that developed materials showed very weak cytotoxicity, good blood compatibility and excellent biological safety comparing to control group.

Keywords

References

  1. M. S. Jacobson, S. V. Kevy, R. Parkman, and J. S. Wesolowski, "An in vitro evaluation of a new plasticizer for polyvinylchloride medical devices," Transfusion, 20(4), 443-447 (1980). https://doi.org/10.1046/j.1537-2995.1980.20480260277.x
  2. J. Sampson, and D. de Korte, "DEHP-plasticised PVC: relevance to blood services," Transfusion Medicine, 21(2), 73-83 (2011). https://doi.org/10.1111/j.1365-3148.2010.01056.x
  3. A. Eveillard, F. Lasserre, M. de Tayrac, A. Polizzi, S. Claus, C. Canlet, L. Mselli-Lakhal, G. Gotardi, A. Paris, H. Guillou, P. G. P. Martin, and T. Pineau, "Identification of potential mechanisms of toxicity after di(2-ethylhexyl)phthalate(DEHP) adult exposure in the liver using a systems biology approach," Toxicology and Applied Pharmacology, 236, 282-292 (2009). https://doi.org/10.1016/j.taap.2009.02.008
  4. U. Heudorf, V. Mersch-Sundermann, and J. Angerer, "Phthalates: Toxicology and exposure," Int. J. Hyg. Environ. Health, 210(5), 623-634 (2007). https://doi.org/10.1016/j.ijheh.2007.07.011
  5. B. H. Shaz, K. Grima, and C. D. Hillyer, "2-(Diethylhexyl) phthalate in blood bags: is this a public health issue?" Transfusion, 51(11), 2510-2517 (2011). https://doi.org/10.1111/j.1537-2995.2011.03164.x
  6. T. O. Greiner, A. S. Volkmann, S. Hildenbrand, R. Wodarz, N. Perle, G. Ziemer, M. Rieger, H. P. Wendel, and T. Walker, "DEHP and its active metabolites: leaching from different tubing types, impact on proinflammatory cytokines and adhesion molecule expression. Is there a subsumable context?" Perfusion, 27(1), 21-29 (2012). https://doi.org/10.1177/0267659111419990
  7. S, S. Hill, B. R. Shaw, and A. H. B. Wu, "The clinical effects of plasticizers, antioxidants, and other," Clinica Chimica Acta, 304(1-2), 1-8 (2001). https://doi.org/10.1016/S0009-8981(00)00411-3
  8. N. Theou, L. Havard, M.-L. Maestroni, P. Prognon, and B. Bonan, "Leaching of di(2-ethylhexyl)phthalate from polyvinyl chloride medical devices: recommendations for taxanes infusion," European J. Hospital Pharmacy Science, 11(3), 55-61 (2005).
  9. A. Treleano, G. Wolz, R. Brandsch, and F. Welle, "Investigation into the sorption of nitroglycerin and diazepam into PVC tubes and alternative tube materials during application," Intl. J. Pharmaceutics, 369(1-2), 30-37 (2009). https://doi.org/10.1016/j.ijpharm.2008.10.024