생체재료학회지 (Biomaterials Research)

  • 제16권3호
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  • Pages.122-128
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  • 2012
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  • 1226-4601(pISSN)
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  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지

토끼 두개골 결손부에서 가교화된 제 1형 콜라겐 차폐막의 초기 골형성 효과

Early Healing Processes in Guided Bone Regeneration using Cross-linked Type-I Collagen Membrane at Rabbit Calvarial Defect

  • 이은웅 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 양혜주 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 황지완 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • ;
  • 정은주 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이중석 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 김창성 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Lee, Eun-Ung (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Yang, Cheryl (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Hwang, Ji-Wan (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Unursaikhan, Otgonbayar (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Jung, Eun-Joo (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Lee, Jung-Seok (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Jung, Ui-Won (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chang-Sung (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Cho, Kyoo-Sung (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
  • 발행 : 2012.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

The aim of this study was to evaluate early healing processes in guided bone regeneration using a cross-linked type- I collagen membrane of 1-ethyl-3-(3- dimethyl aminopropyl) carbodiimide (EDC) at rabbit calvarial defects. Eight male New Zealand rabbits were used and four circular calvarial defects were created. Each of the four defects was filled with different graft materials: 1) collagen membrane, 2) biphasic calcium phosphate, 3) collagen membrane with biphasic calcium phosphate, and 4) nothing as control. The animals were sacrificed following two and four weeks of healing periods. Between two healing periods, collagen membrane was resorbed 28.5% and maintained its original shape and marginal integrity. The collagen membrane group resulted in significantly better defect closure compared to control group (p < 0.05). The augmented area was significantly higher in bone graft material applied groups (p < 0.05). There was no statistical difference in new bone formation between all groups at all healing periods, but vascularization was seemed to be promoted and more new bone formation was observed in superficial layer in collagen membrane applied groups. Within the limits of this study, the cross linked collagen membrane maintained its structural integrity and promoted bone regeneration especially in superficial layer.

키워드

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