Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Recent Advances in a Dual-ligand Approach for Cancer Targeting

이중 리간드를 이용한 암 표적지향의 최근 연구동향

  • Bae, Jin Woo (Department of Molecular Science and Technology, Ajou University) ;
  • Park, Ki Dong (Department of Molecular Science and Technology, Ajou University)
  • 배진우 (아주대학교 분자과학기술학과) ;
  • 박기동 (아주대학교 분자과학기술학과)
  • Published : 2012.09.01
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Abstract

For the past few decades, great advances have been made in cancer treatment using targeted drug delivery systems that utilize specific receptor-ligand interactions. Some targeted nanocarriers have shown clinically promising results. Considering cancer microenvironments that are very complex and dynamic, however, nanocarrier-based drug delivery platforms decorated with a single ligand that can specifically bind to receptors over-expressed on cancer cells may cause adverse effects because the ligand can be also recognized by normal cells. This review mainly focuses on a dual-ligand approach of nanocarriers that simultaneously exploits two different types of cancer targeting ligands, which can improve cancer targetability of the nanocarriers. We will first discuss general features of current nanocarrier platforms in brief and then introduce the recent achievement based on a dual-ligand approach.

Keywords

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