Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Fucoidan Based Nanocomplex for Improving Antioxidant Activity of Anthocyanin

안토시아닌의 항산화 활성 증진을 위한 후코이단 기반의 나노이온복합체

  • Min, Daehong (Department of Biotechnology, The Catholic University of Korea) ;
  • Na, Kun (Department of Biotechnology, The Catholic University of Korea)
  • 민대홍 (가톨릭대학교 생명공학과) ;
  • 나건 (가톨릭대학교 생명공학과)
  • Published : 2012.06.01
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Abstract

To improve the antioxidant efficiency of anthocyanin, fucoidan-anthocyanin nanocomplex has been investigated. The nanocomplex was fabricated by simple process in water phase to minimize loss of anthocyanin. In the nanocomplex, structure of anthocyanin was changed from flavylium cation to quinoidal base structure. Between 200 to 300 nm of spherical nanocomplex was observed by dynamic light scattering (DLS) and field emission scanning electron microscopy (FE-SEM). The nanocomplex has 10 fold lower critical assemble concentration (CAC) value (0.025 mg/ml) than free anthocyanin (0.25 mg/ml). The radical scavenging rate of anthocyanin against DPPH radicals and hydrogen peroxide were improved from 76% to 79% and from 20% to 60%, respectively. Finally, anticancer activity of anthocyanin was measured to estimate the in vitro radical scavenging activity. In the lipopolysaccharide (LPS) mediated reactive oxygen species (ROS) rich condition, the nanocomplex effectively reduced cancer cells viability (77%) to compared with free anthocyanin (121%). Therefore, we conclude that fucoidan-anthocyanin nanocomplex has a potential for use as a carrier for anthocyanin delivery. These nanocomplexes would prove useful application in the food, beverage and pharmaceutical industries.

Keywords

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