생체재료학회지 (Biomaterials Research)

  • 제16권1호
  • /
  • Pages.25-31
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  • 2012
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  • 1226-4601(pISSN)
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  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지

히알루론산 함유 폴리비닐알콜 하이드로겔 패치의 제조 및 창상 치유 효능 평가

Fabrication of Hyaluronic Acid-Loaded Polyvinyl Alcohol Hydrogel Patch and Evaluation of Wound Healing Efficacy

  • 남보라 (한남대학교 신소재공학과) ;
  • 오세행 (한남대학교 신소재공학과) ;
  • 김상준 (한남대학교 신소재공학과) ;
  • 강동영 (한남대학교 화학과) ;
  • 이승호 (한남대학교 화학과) ;
  • 송규상 (충남대학교병원 병리과) ;
  • 이진호 (한남대학교 신소재공학과)
  • Nam, Bo Ra (Department of Advanced Materials, Hannam University) ;
  • Oh, Se Heang (Department of Advanced Materials, Hannam University) ;
  • Kim, Sang June (Department of Advanced Materials, Hannam University) ;
  • Kang, Dong Young (Department of Chemistry, Hannam University) ;
  • Lee, Seungho (Department of Chemistry, Hannam University) ;
  • Song, Kyu Sang (Department of Pathology, School of Medicine, Chungnam National University) ;
  • Lee, Jin Ho (Department of Advanced Materials, Hannam University)
  • 발행 : 2012.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

In this study, we fabricated hyaluronic acid (HA)-loaded polyvinyl alcohol (PVA) hydrogel patches as a wound dressing by a simple freezing/thawing method to estimate the effect of HA addition and its molecular weight (MW) during the wound healing. The molecular weight of HA was controlled by a $\gamma$-ray irradiation [HA with high MW (HHA, ~4,800 kDa) & HA with low MW (LHA, ~52 kDa)]. The prepared PVA/HA hydrogel patches were flexible and elastic, and had a high swelling property in water. The wound healing behavior of the PVA/HA hydrogel patches were compared with those of PVA hydrogel patch as well as gauze (control) using SD rats as a wound model. It was observed that the PVA/HA hydrogel patches had faster wound healing behavior than gauze and PVA patch groups, regardless of molecular weight of HA. It is probably owing to the synergistic effect of PVA which allows the fast absorption of exudate from wound and provides wet environment for wound, and HA which provides the stimulation of cell proliferation for wound healing. It was also observed that the PVA/HHA hydrogel patch showed more effective wound healing behavior than the PVA/LHA one, however, the difference is not significant. This result suggests that the PVA/ HA hydrogel patch can be a good candidate as a dressing material for effective wound healing.

키워드

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